3,316 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Electroporated recombinant proteins as tools for in vivo functional complementation, imaging and chemical biology

    Amal Alex, Valentina Piano ... Stefano Maffini
    An electroporation-based method allows the direct delivery of recombinant proteins into mammalian cells for in vivo functional studies.
    1. Epidemiology and Global Health
    2. Immunology and Inflammation

    A recombinant protein containing influenza viral conserved epitopes and superantigen induces broad-spectrum protection

    Yansheng Li, Mingkai Xu ... Chenggang Zhang
    By fusing influenza viral conserved epitopes and a superantigen fragment, we constructed a recombinant protein that might be a candidate universal broad-spectrum vaccine for the prevention and treatment of multiple influenza viruses.
    1. Immunology and Inflammation

    Ym1 protein crystals promote type 2 immunity

    Ines Heyndrickx, Kim Deswarte ... Bart N Lambrecht
    Protein crystallization is a rare event yet Ym1 crystals made from a chitinase-like protein are abundantly found in eosinophilic airway inflammation, where they promote type 2 immunity.
    1. Epidemiology and Global Health

    Identification of highly-protective combinations of Plasmodium vivax recombinant proteins for vaccine development

    Camila Tenorio França, Michael T White ... Ivo Mueller
    Antibody responses to individual and optimal combinations of P. vivax recombinant proteins in naturally-exposed populations help to identify correlates of protective immunity, and establish a clear path to testing a multicomponent P. vivax vaccine.
    1. Biochemistry and Chemical Biology

    Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates

    Matthew E Cockman, Kerstin Lippl ... Peter J Ratcliffe
    Assays using recombinant HIF prolyl hydroxylases did not support hydroxylation of more than 20 reported non-HIF substrates under conditions where robust HIF hydroxylation was observed.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Generation and diversification of recombinant monoclonal antibodies

    Keith F DeLuca, Jeanne E Mick ... Jennifer G DeLuca
    Tools and methodologies to create and diversify recombinant antibodies and antibody fragments provide researchers with the ability to generate low-cost, high-yield immunological reagents.
    1. Cell Biology

    Phosphoproteomic mapping reveals distinct signaling actions and activation of muscle protein synthesis by Isthmin-1

    Meng Zhao, Niels Banhos Danneskiold-Samsøe ... Katrin J Svensson
    The role of Isthmin-1 in muscle function is defined by using phosphoproteomics to identify distinct and overlapping signaling pathways between Isthmin-1 and insulin.
    1. Neuroscience

    A toolbox of IgG subclass-switched recombinant monoclonal antibodies for enhanced multiplex immunolabeling of brain

    Nicolas P Andrews, Justin X Boeckman ... James S Trimmer
    This paper describes an effective pipeline for conversion of conventional monoclonal antibodies into recombinant form that results in an IgG subclass switch that greatly expands their utility for multiplex labeling.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Extended low-resolution structure of a Leptospira antigen offers high bactericidal antibody accessibility amenable to vaccine design

    Ching-Lin Hsieh, Christopher P Ptak ... Yung-Fu Chang
    The antibody accessibility of the leptospiral surface protein, LigB, provides a guide for the rational design of improved recombinant chimeric vaccine antigens displayed on a single domain scaffold.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Robust cullin-RING ligase function is established by a multiplicity of poly-ubiquitylation pathways

    Spencer Hill, Kurt Reichermeier ... Gary Kleiger
    Human cullin-RING ligases are buffered to a much greater extent than had been previously appreciated, and the roles of ubiquitin chain extension enzymes are far more nuanced at physiological concentrations.

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