10,420 results found
    1. Genetics and Genomics

    Repeated losses of PRDM9-directed recombination despite the conservation of PRDM9 across vertebrates

    Zachary Baker, Molly Schumer ... Molly Przeworski
    PRDM9 is widely conserved across vertebrates yet has been lost numerous times, as has its role in directing meiotic recombination.
    1. Evolutionary Biology

    Whole genome phylogenies reflect the distributions of recombination rates for many bacterial species

    Thomas Sakoparnig, Chris Field, Erik van Nimwegen
    For many bacterial species, recombination dominates genome evolution and phylogenetic patterns that have so far been assumed to reflect clonal relationships, in fact reflect variation in recombination rates across lineages.
    1. Chromosomes and Gene Expression
    2. Immunology and Inflammation

    Senataxin and RNase H2 act redundantly to suppress genome instability during class switch recombination

    Hongchang Zhao, Stella R Hartono ... Jacqueline Barlow
    Genetic analysis of senataxin and RNase H2-deficient mice reveals that genome stability during class switch recombination and antibody generation can be uncoupled, suggesting a role for R loop metabolism dysfunction in lymphomagenesis in patients without immune deficiency.
    1. Chromosomes and Gene Expression

    The kinetochore prevents centromere-proximal crossover recombination during meiosis

    Nadine Vincenten, Lisa-Marie Kuhl ... Adèle L Marston
    The meiotic DNA recombination landscape is locally influenced by the kinetochore to minimize potentially deleterious pericentromeric crossover recombination.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    The role of interspecies recombination in the evolution of antibiotic-resistant pneumococci

    Joshua C D'Aeth, Mark PG van der Linden ... The GPS Consortium
    Selection by national-level antibiotic consumption and vaccination trends drives atypical recombinations, frequently resulting in interspecies sequence exchange at many sites across a bacterial species’ chromosome.
    1. Biochemistry and Chemical Biology

    Random-sequence genetic oligomer pools display an innate potential for ligation and recombination

    Hannes Mutschler, Alexander I Taylor ... Philipp Holliger
    Random sequence RNA pools display an innate capacity for ligation and recombination, enabling them to “bootstrap” themselves towards higher compositional, informational and structural complexity.
    1. Genetics and Genomics

    Recombination, meiotic expression and human codon usage

    Fanny Pouyet, Dominique Mouchiroud ... Marie Sémon
    Variation in codon usage among functional categories of human genes is not due to selection for translation efficiency, but to differences in intragenic recombination rate, linked to variation in meiotic transcription level.
    1. Chromosomes and Gene Expression

    High-resolution mapping of heteroduplex DNA formed during UV-induced and spontaneous mitotic recombination events in yeast

    Yi Yin, Margaret Dominska ... Thomas D Petes
    Genome-wide mapping of heteroduplex DNA (a recombination intermediate) formed during mitotic recombination in yeast demonstrates that the "classical" model of double-strand DNA break repair is inadequate to explain several aspects of mitotic recombination.
    1. Chromosomes and Gene Expression

    Histone H3G34R mutation causes replication stress, homologous recombination defects and genomic instability in S. pombe

    Rajesh K Yadav, Carolyn M Jablonowski ... Janet F Partridge
    Mutation of Glycine 34 to Arginine within the N-terminal tail of histone H3 alters post-translational modifications on Lysine 36 and is associated with a delay in replication restart, defective homologous recombination and an increase in genomic instability.
    1. Immunology and Inflammation

    Combining genotypes and T cell receptor distributions to infer genetic loci determining V(D)J recombination probabilities

    Magdalena L Russell, Aisha Souquette ... Philip Bradley
    Trans genetic variation in TdT and Artemis loci impacts V(D)J recombination probabilities.

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