12,273 results found
    1. Neuroscience

    A model of hippocampal replay driven by experience and environmental structure facilitates spatial learning

    Nicolas Diekmann, Sen Cheng
    A model of hippocampal replay is proposed that gives a biologically plausible account of how the hippocampus could prioritize replay and produce a variety of different replay statistics, and is efficient in driving spatial learning.
    1. Neuroscience

    Experience-driven rate modulation is reinstated during hippocampal replay

    Margot Tirole, Marta Huelin Gorriz ... Daniel Bendor
    Hippocampal place cells modulate their firing rate during replay events to reflect the increases, or decreases, in firing rate experienced between contexts during behavior.
    1. Neuroscience

    The roles of online and offline replay in planning

    Eran Eldar, Gaëlle Lièvre ... Raymond J Dolan
    Replay of recently experienced trajectories during a decision task is coupled with more effective adaptation to change, whereas replay during rest is associated with limited decision making flexibility.
    1. Computational and Systems Biology
    2. Developmental Biology

    Tuned polymerization of the transcription factor Yan limits off-DNA sequestration to confer context-specific repression

    C Matthew Hope, Jemma L Webber ... Ilaria Rebay
    Tuned protein–protein interaction affinity optimizes the repressive function of the ETS family transcription factor Yan in order to contribute specificity and robustness to cell fate specification in the developing Drosophila eye.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Adaptation of hepatitis C virus to interferon lambda polymorphism across multiple viral genotypes

    Nimisha Chaturvedi, Evguenia S Svarovskaia ... Jacques Fellay
    Integrated analysis of IFN-λ and HCV amino acid variation indicates the key role of host innate immunity in viral control.
    1. Neuroscience

    Offline replay supports planning in human reinforcement learning

    Ida Momennejad, A Ross Otto ... Kenneth A Norman
    fMRI evidence for off-task replay predicts subsequent replanning behavior in humans, suggesting that learning from simulated experience during replay helps update past policies in reinforcement learning.
    1. Neuroscience

    Hippocampal replay of experience at real-world speeds

    Eric L Denovellis, Anna K Gillespie ... Loren M Frank
    A new state space decoder revealed that most hippocampal sharp-wave ripples contain coherent spatial content, and that this 'replay' typically progresses at speeds similar to those seen during actual experiences.
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    A genome-to-genome analysis of associations between human genetic variation, HIV-1 sequence diversity, and viral control

    István Bartha, Jonathan M Carlson ... Jacques Fellay
    An innovative strategy in genome analysis has generated a detailed description of how pathogens mutate when facing human genetic diversity.
    1. Physics of Living Systems

    The importance of intermediate filaments in the shape maintenance of myoblast model tissues

    Irène Nagle, Florence Delort ... Myriam Reffay
    Specific to muscles and essential for their development, desmin is revealed to be fundamental to the mechanics and shape maintenance of model muscle tissue even in early differentiating and unorganized systems through an integrated magnetic tensiometer approach.
    1. Neuroscience

    Irregular spiking of pyramidal neurons organizes as scale-invariant neuronal avalanches in the awake state

    Timothy Bellay, Andreas Klaus ... Dietmar Plenz
    Spontaneous, irregular spiking in single cortical pyramidal neurons assembles as neuronal avalanches at the group level identifying a robust scale-invariant organization of resting activity in the awake state.

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