118 results found
    1. Genetics and Genomics
    2. Microbiology and Infectious Disease

    Interdependent progression of bidirectional sister replisomes in E. coli

    Po Jui Chen, Anna B McMullin ... David Bates
    Physical association between sister replisomes early in the E. coli replication phase promotes rapid fork progression and inhibits fork stalling.
    1. Cell Biology

    Transcription leads to pervasive replisome instability in bacteria

    Sarah M Mangiameli, Christopher N Merrikh ... Houra Merrikh
    Replication-transcription conflicts cause pervasive replisome instability.
    1. Structural Biology and Molecular Biophysics

    Single-molecule visualization of fast polymerase turnover in the bacterial replisome

    Jacob S Lewis, Lisanne M Spenkelink ... Antoine M van Oijen
    The canonical model that the bacterial replisome tightly holds on to its polymerases is challenged by the visualization of rapid holoenzyme exchange, both in vitro and in vivo.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    The interplay of RNA:DNA hybrid structure and G-quadruplexes determines the outcome of R-loop-replisome collisions

    Charanya Kumar, Sahil Batra ... Dirk Remus
    Reconstitution of orientation-specific R-loop-replisome collisions with purified proteins reveals the differential impact of R-loop-associated RNA:DNA hybrids and G-quadruplexes on replication fork progression.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Mcm10 promotes rapid isomerization of CMG-DNA for replisome bypass of lagging strand DNA blocks

    Lance D Langston, Ryan Mayle ... Mike E O'Donnell
    Biochemical data demonstrate an unexpected and critical function for the enigmatic Mcm10 protein in helping the eukaryotic CMG helicase/replisome bypass roadblocks on the DNA that may also explain Mcm10 function at origins of replication.
    1. Physics of Living Systems

    Speed variations of bacterial replisomes

    Deepak Bhat, Samuel Hauf ... Simone Pigolotti
    The speed of replisomes in Escherichia coli depends on temperature and varies along the genome in a wave-like manner, with implications for bacterial physiology.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Frequent exchange of the DNA polymerase during bacterial chromosome replication

    Thomas R Beattie, Nitin Kapadia ... Rodrigo Reyes-Lamothe
    DnaB Helicase is the only stable component of the bacterial replisome as the replicative DNA polymerase frequently exchanges in both leading and lagging strands.
    1. Cell Biology

    Replisome loading reduces chromatin motion independent of DNA synthesis

    Maruthi Kumar Pabba, Christian Ritter ... M Cristina Cardoso
    Live cell tracking of labeled DNA reveals that replisome loading rather than DNA synthesis decreases the chromatin motion during S-phase in human cells.
    1. Biochemistry and Chemical Biology

    Ctf4 organizes sister replisomes and Pol α into a replication factory

    Zuanning Yuan, Roxana Georgescu ... Huilin Li
    Eukaryotic replisomes are strongly connected together to replicate both sister DNAs produced from a bidirectional origin.
    1. Chromosomes and Gene Expression

    TRAIP drives replisome disassembly and mitotic DNA repair synthesis at sites of incomplete DNA replication

    Remi Sonneville, Rahul Bhowmick ... Karim Labib
    The TRAIP ubiquitin ligase is required during mitosis to disassemble the replisome at sites of incomplete DNA replication, and activate the mitotic DNA repair pathway, thus preserving genome integrity.
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