960 results found
    1. Neuroscience

    Non-rapid eye movement sleep determines resilience to social stress

    Brittany J Bush, Caroline Donnay ... J Christopher Ehlen
    Pre-existing variability in the regulation of non-rapid eye movement sleep predicts resilience to social-defeat stress.
    1. Chromosomes and Gene Expression

    CTCF confers local nucleosome resiliency after DNA replication and during mitosis

    Nick Owens, Thaleia Papadopoulou ... Pablo Navarro
    In contrast to other transcription factors, CTCF and Esrrb rapidly regain binding after replication and remain bound to their targets during mitosis, preserving local nucleosome organization throughout the cell cycle.
    1. Computational and Systems Biology

    Automated, high-dimensional evaluation of physiological aging and resilience in outbred mice

    Zhenghao Chen, Anil Raj ... Adam Freund
    A non-invasive animal monitoring system paired with a custom analysis pipeline allows organism-level aging to be studied with improved throughput, resolution, and physiological scope while reducing the activation energy that comes with highly specialized challenge-based procedures.
    1. Epidemiology and Global Health

    Building resilient cervical cancer prevention through gender-neutral HPV vaccination

    Irene Man, Damien Georges ... Iacopo Baussano
    Shifting from girls-only to gender-neutral HPV vaccination strategy improves the resilience of cervical cancer prevention and enhances progress towards cervical cancer elimination.
    1. Epidemiology and Global Health

    Adverse childhood experiences and resilience among adult women: A population-based study

    Hilda Björk Daníelsdóttir, Thor Aspelund ... Unnur Anna Valdimarsdóttir
    Cumulative exposure to adverse childhood experiences is associated with lower adult resilience among women in a dose-dependent manner, independent of adult socioeconomic factors and social support, indicating that adult female resilience is consolidated in early life.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Mutational resilience of antiviral restriction favors primate TRIM5α in host-virus evolutionary arms races

    Jeannette L Tenthorey, Candice Young ... Harmit S Malik
    Mutations in the TRIM5α retrovirus-binding interface frequently improve but rarely disrupt retroviral restriction.
    1. Neuroscience

    Noise-induced plasticity of KCNQ2/3 and HCN channels underlies vulnerability and resilience to tinnitus

    Shuang Li, Bopanna I Kalappa, Thanos Tzounopoulos
    Mice that successfully avoid developing tinnitus despite exposure to excessive noise show spontaneous recovery of KCNQ2/3 potassium channel activity associated with a reduction in HCN channel activity in auditory brainstem neurons.
    1. Neuroscience

    Region-specific myelin differences define behavioral consequences of chronic social defeat stress in mice

    Valentina Bonnefil, Karen Dietz ... Jia Liu
    Myelination in the medial prefrontal cortex defines behavioral consequences to social stress.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Measurements of damage and repair of binary health attributes in aging mice and humans reveal that robustness and resilience decrease with age, operate over broad timescales, and are affected differently by interventions

    Spencer Farrell, Alice E Kane ... Andrew D Rutenberg
    Damage and repair for both aging mice and humans declined with age, exhibited very long timescales that varied across health attributes, and were differently affected by interventions.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Two novel, tightly linked, and rapidly evolving genes underlie Aedes aegypti mosquito reproductive resilience during drought

    Krithika Venkataraman, Nadav Shai ... Leslie B Vosshall
    Two novel, tightly linked, and rapidly evolving genes encoding small secreted proteins are necessary for female mosquitoes to protect their retained eggs during extended periods of drought.

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