141 results found
    1. Epidemiology and Global Health
    2. Microbiology and Infectious Disease

    Resistome diversity in cattle and the environment decreases during beef production

    Noelle R Noyes, Xiang Yang ... Keith E Belk
    Interventions in feedlots and abattoirs place selective pressure on the beef cattle resistome, which differentially impacts the public health risk of antimicrobial resistance from beef production sources.
    1. Microbiology and Infectious Disease

    Mobilome-driven segregation of the resistome in biological wastewater treatment

    Laura de Nies, Susheel Bhanu Busi ... Paul Wilmes
    Biological wastewater treatment plants are critical reservoirs of antimicrobial resistance (AMR), allowing for early detection and monitoring of resistant pathogens, whilst serving as models for understanding the segregation of mobile genetic elements through AMR.
    1. Ecology
    2. Epidemiology and Global Health

    Ecology, more than antibiotics consumption, is the major predictor for the global distribution of aminoglycoside-modifying enzymes

    Léa Pradier, Stéphanie Bedhomme
    Mobility across ecological contexts and continents is more important to describe the worldwide spread of bacterial resistance to aminoglycosides (a family of antibiotics), than the consumption of aminoglycosides itself.
    1. Computational and Systems Biology
    2. Evolutionary Biology

    Evolved bacterial resistance to the chemotherapy gemcitabine modulates its efficacy in co-cultured cancer cells

    Serkan Sayin, Brittany Rosener ... Amir Mitchell
    Mutations conferring resistance to Escherichia coli against the chemotherapy drug gemcitabine can have opposite effects on bacterial drug degradation and therefore can increase or decrease the chemotherapy load on neighboring cancer cells.
    1. Physics of Living Systems

    Mitigating memory effects during undulatory locomotion on hysteretic materials

    Perrin E Schiebel, Henry C Astley ... Daniel I Goldman
    Undulatory animals moving on the surface must manage material memory by either having a slender anatomy that facilitates avoiding previously remodeled substrate, or using waveshapes that effectively utilize the memory.
    1. Neuroscience

    Robotic multi-probe single-actuator inchworm neural microdrive

    Richard D Smith, Ilya Kolb ... Mladen Barbic
    A novel micropositioning approach allows remote-controlled, micrometer-resolution actuation of many densely packed, arbitrarily shaped probes with a device whose size and weight scale much more efficiently with probe count compared to current methods.
    1. Plant Biology

    An N-terminal motif in NLR immune receptors is functionally conserved across distantly related plant species

    Hiroaki Adachi, Mauricio P Contreras ... Sophien Kamoun
    The MADA motif is functionally conserved across NLRs from distantly related plants and has degenerated in sensor NLRs over evolutionary time.
    1. Computational and Systems Biology

    Evolved bacterial resistance against fluoropyrimidines can lower chemotherapy impact in the Caenorhabditis elegans host

    Brittany Rosener, Serkan Sayin ... Amir Mitchell
    Bacterial evolutionary adaptation to two chemotherapy drugs can lead to changes in bacterial metabolism and impact drug toxicity in a worm host.
    1. Microbiology and Infectious Disease
    2. Physics of Living Systems

    Coordination of two opposite flagella allows high-speed swimming and active turning of individual zoospores

    Quang D Tran, Eric Galiana ... Xavier Noblin
    Coordinated actions of two opposite flagella control speed and change direction of plant pathogen Phytophthora zoospores, in which the anterior flagellum is the main motor to generate thrust and spontaneously switch from reciprocal beating to breaststrokes to reorient its body.
    1. Structural Biology and Molecular Biophysics

    Unmasking coupling between channel gating and ion permeation in the muscle nicotinic receptor

    John R Strikwerda, Steven M Sine
    Mutating a highly conserved intramembrane salt bridge unmasks structural and functional coupling between channel gating and ion permeation in the muscle nicotinic receptor.

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