Retinal visual response properties in awake mice are similar to those under anesthesia or ex vivo, but not exactly the same, so knowledge of retinal function cannot be simply translated from ex vivo to in vivo.
A molecular atlas of the chick retina provides a comprehensive classification and characterization of 136 cell types, yielding novel insights into retinal structure, function, development, and evolution.
Kaushikaram Subramanian, Martin Weigert ... Moritz Kreysing
Establishing retinal contrast transmission as a novel determinant of mammalian fitness, this research adds functional significance to a prominent exception of nuclear organization, previously described in nocturnal rod photoreceptor cells.
A preclinical study using exogenous retinoids in a novel Usher syndrome 1F mouse model reveals a possible therapy to treat mutant PCDH15-mediated visual dysfunction.
David Sokolov, Emily R Sechrest ... Saravanan Kolandaivelu
NMNAT1, a ubiquitously expressed metabolic enzyme linked to inherited blinding disease, is crucial for the proper differentiation of photoreceptor cells and subsequent survival of multiple cell types in the retina.
Genome-wide analysis of DNA methylation and accessible chromatin shows that retinal rods and cones have distinct epigenomic features that reflect differences in their development and function.
Jasper J Visser, Yolanda Cheng ... Woj M Wojtowicz
An integrated approach for studying laminar organization in the developing mouse retina identifies two families of extracellular recognition proteins that mediate neuronal subtype-specific recognition.
Christiane Voufo, Andy Quaen Chen ... Alexandre Tiriac
Calcium imaging reveals spatiotemporal properties of correlated spontaneous activity in the embryonic retina and implicates a role for electrical and chemical synapses in generating the activity.
