540 results found
    1. Neuroscience

    The cell adhesion molecule Sdk1 shapes assembly of a retinal circuit that detects localized edges

    Pierre-Luc Rochon, Catherine Theriault ... Arjun Krishnaswamy
    A novel retinal ganglion cell requires a cell adhesion molecule to grow its dendrites, collect synaptic inputs, and become selective to edges placed in its receptive field.
    1. Neuroscience

    Circuit mechanisms underlying embryonic retinal waves

    Christiane Voufo, Andy Quaen Chen ... Alexandre Tiriac
    Calcium imaging reveals spatiotemporal properties of correlated spontaneous activity in the embryonic retina and implicates a role for electrical and chemical synapses in generating the activity.
    1. Neuroscience

    Spatially displaced excitation contributes to the encoding of interrupted motion by a retinal direction-selective circuit

    Jennifer Ding, Albert Chen ... Wei Wei
    The direction-selective circuit in the retina adjusts the contributions of excitatory and inhibitory mechanisms under different stimulus conditions to generate context-dependent neural representations of visual features.
    1. Neuroscience

    Formation of retinal direction-selective circuitry initiated by starburst amacrine cell homotypic contact

    Thomas A Ray, Suva Roy ... Jeremy N Kay
    Selective synapse formation in a retinal motion-sensitive circuit is orchestrated by starburst amacrine cells, which use homotypic interactions to initiate formation of a dendritic scaffold that recruits projections from circuit partners.
    1. Developmental Biology

    Strip1 regulates retinal ganglion cell survival by suppressing Jun-mediated apoptosis to promote retinal neural circuit formation

    Mai Ahmed, Yutaka Kojima, Ichiro Masai
    A neuroprotective role mediated by Strip1 maintains retinal ganglion cells during development, which ensures proper positioning of inner retinal neurons and preserves the laminar architecture of the inner retina.
    1. Neuroscience

    Connectomic analysis reveals an interneuron with an integral role in the retinal circuit for night vision

    Silvia JH Park, Evan E Lieberman ... Joshua H Singer
    Anatomical and physiological analyses identified an inhibitory interneuron that is an integral part of the rod bipolar cell pathway, the circuit for night vision, of the mammalian retina.
    1. Neuroscience

    Divisive suppression explains high-precision firing and contrast adaptation in retinal ganglion cells

    Yuwei Cui, Yanbin V Wang ... Daniel A Butts
    The convergence of two visual pathways at the level of retinal bipolar cells accounts for key features of ganglion cell responses.
    1. Chromosomes and Gene Expression
    2. Neuroscience

    The LIM protein complex establishes a retinal circuitry of visual adaptation by regulating Pax6 α-enhancer activity

    Yeha Kim, Soyeon Lim ... Jin Woo Kim
    Regulation of Pax6 expression through the α-enhancer fine-tunes amacrine cell subtype number, and consequently, the visual output of the retina.
    1. Neuroscience

    A simple retinal mechanism contributes to perceptual interactions between rod- and cone-mediated responses in primates

    William N Grimes, Logan R Graves ... Fred Rieke
    A combination of physiological and perceptual experiments show that the responses of rod photoreceptors inhibit those of cones more than vice versa, and reveal both the site of the retinal interaction and the underlying mechanism.
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    1. Neuroscience

    Controlling gain one photon at a time

    Gregory W Schwartz, Fred Rieke
    Single absorbed photons trigger adaptational mechanisms that help the retina maintain sensitivity across a wide range of background illumination.

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