179 results found
    1. Developmental Biology
    2. Neuroscience

    Neural retina-specific Aldh1a1 controls dorsal choroidal vascular development via Sox9 expression in retinal pigment epithelial cells

    So Goto, Akishi Onishi ... Masayo Takahashi
    Neural retina-derived retinoic acids synthesized by Aldh1a1 control choroidal vascular development by regulating RPE-secreted VEGF.
    1. Biochemistry and Chemical Biology
    2. Neuroscience

    Biochemical adaptations of the retina and retinal pigment epithelium support a metabolic ecosystem in the vertebrate eye

    Mark A Kanow, Michelle M Giarmarco ... James B Hurley
    Metabolic relationships between cells in the retina and retinal pigment epithelium are fundamental to retinal function, retinal disease and age-related vision loss and they may provide strategies for metabolism-based therapies.
    1. Developmental Biology
    2. Neuroscience

    Stretching of the retinal pigment epithelium contributes to zebrafish optic cup morphogenesis

    Tania Moreno-Mármol, Mario Ledesma-Terrón ... Paola Bovolenta
    Retinal pigment epithelium flattening is an efficient solution adopted by the fast-developing zebrafish to enable folding of the eye primordia, which contrasts with the proliferation-based mechanism used by amniotes.
    1. Neuroscience

    Impaired ABCA1/ABCG1-mediated lipid efflux in the mouse retinal pigment epithelium (RPE) leads to retinal degeneration

    Federica Storti, Katrin Klee ... Christian Grimm
    Lipid efflux by the retinal pigment epithelium is crucial for proper retinal integrity and function, and its impairment may contribute to diseases like age-related macular degeneration.
    1. Medicine
    2. Stem Cells and Regenerative Medicine

    Merging organoid and organ-on-a-chip technology to generate complex multi-layer tissue models in a human retina-on-a-chip platform

    Kevin Achberger, Christopher Probst ... Peter Loskill
    A microphysiological system (retina-on-a-chip) shows the potential to promote drug development and provide new insights into the underlying pathology of retinal diseases.
    1. Cell Biology
    2. Neuroscience

    Hypoxia-induced metabolic stress in retinal pigment epithelial cells is sufficient to induce photoreceptor degeneration

    Toshihide Kurihara, Peter D Westenskow ... Martin Friedlander
    Mouse models in which hypoxia can be genetically triggered in retinal pigmented epithelial cells show that hypoxia-induced metabolic stress alone can lead to photoreceptor atrophy/dysfunction.
    1. Computational and Systems Biology
    2. Stem Cells and Regenerative Medicine

    Robotic search for optimal cell culture in regenerative medicine

    Genki N Kanda, Taku Tsuzuki ... Tohru Natsume
    Robotic AI system automated discovery of optimum cell culture protocol, a most experience-dependent process in regenerative medicine.
    1. Neuroscience

    The β-alanine transporter BalaT is required for visual neurotransmission in Drosophila

    Yongchao Han, Liangyao Xiong ... Tao Wang
    BalaT-dependent β-alanine trafficking pathway in retinal pigment cells is critical for maintaining synaptic transmission of photoreceptor neurons in Drosophila.
    1. Neuroscience

    Disturbed retinoid metabolism upon loss of rlbp1a impairs cone function and leads to subretinal lipid deposits and photoreceptor degeneration in the zebrafish retina

    Domino K Schlegel, Srinivasagan Ramkumar ... Stephan CF Neuhauss
    The retinoid-binding protein RLBP1 in the retinal pigment epithelium is crucially involved in cone photoreceptor visual pigment recycling and mimics the human eye disease with retinal lipid deposits when mutated.
    1. Developmental Biology
    2. Neuroscience

    Revisiting the role of Dcc in visual system development with a novel eye clearing method

    Robin J Vigouroux, Quénol Cesar ... Kim Tuyen Nguyen-Ba-Charvet
    A new eye-specific Dcc mutant combined with an improved clearing protocol for the eye and brain (EyeDISCO) reveals the requirement of the receptor Dcc for retinal development and maintenance.

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