Bhargavi Jayaraman, David C Crosby ... Alan D Frankel
A pliable hydrophobic interface in the HIV-1 Rev protein enables assembly of diverse oligomeric structures, guided by the RRE scaffold present in HIV-1 mRNAs.
The nuclear export receptor Crm1 cooperatively binds its HIV Rev-RRE cargo as a dimer using a species-specific interface that supports viral replication by enhancing nuclear export of HIV RNA.
Tertiary folding of the Rev-response element (RRE) in HIV RNA ensures the rapid formation of the Rev-RRE viral ribonucleoprotein particle via a two-step process.
Percy Griffin, Patrick W Sheehan ... Erik S Musiek
The BMAL1-REV-ERB axis controls expression of complement C4b expression and microglial synaptic phagoctyosis, providing a link between cellular circadian clock function and synaptic regulation.
A proximity labeling approach defines germ granule proteome in Caenorhabditis elegans, and identifies LOTUS domain proteins as key regulators of germ granule assembly.
Ancient protein domains remain shaped by amino acid availability during early life, while young animal proteins are shaped by a need for high intrinsic structural disorder.
Maliheh Safari, Bhargavi Jayaraman ... Alan D Frankel
The HIV proteins Env and Rev encode helices that overlap in the viral genome but alternate in functional importance so that the non-functional surface of one helix encodes the functional surface of the other.
Mahlon A Collins, Gemechu Mekonnen, Frank Wolfgang Albert
Genetic mapping reveals widespread, complex genetic effects on protein degradation by the ubiquitin-proteasome system, the primary protein degradation pathway in eukaryotic cells.
Florian Mattenberger, Victor Latorre ... Ron Geller
Comprehensive analyses of how mutations in a picornavirus capsid affect viral fitness provide novel insights into viral biology, evolution, and host interactions.
Andrew R Crowley, Harini Natarajan ... Margaret E Ackerman
Non-neutralizing antibodies to the SARS-CoV-2 spike protein’s S2 domain that also recognize widely circulating endemic coronavirus strains are rapidly boosted by natural infection but not vaccination with stabilized spike-based vaccines.