1,458 results found
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    RNA-directed remodeling of the HIV-1 protein Rev orchestrates assembly of the Rev–Rev response element complex

    Bhargavi Jayaraman, David C Crosby ... Alan D Frankel
    A pliable hydrophobic interface in the HIV-1 Rev protein enables assembly of diverse oligomeric structures, guided by the RRE scaffold present in HIV-1 mRNAs.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    The export receptor Crm1 forms a dimer to promote nuclear export of HIV RNA

    David S Booth, Yifan Cheng, Alan D Frankel
    The nuclear export receptor Crm1 cooperatively binds its HIV Rev-RRE cargo as a dimer using a species-specific interface that supports viral replication by enhancing nuclear export of HIV RNA.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    RNA-guided assembly of Rev-RRE nuclear export complexes

    Yun Bai, Akshay Tambe ... Jennifer A Doudna
    Tertiary folding of the Rev-response element (RRE) in HIV RNA ensures the rapid formation of the Rev-RRE viral ribonucleoprotein particle via a two-step process.
    1. Neuroscience

    REV-ERBα mediates complement expression and diurnal regulation of microglial synaptic phagocytosis

    Percy Griffin, Patrick W Sheehan ... Erik S Musiek
    The BMAL1-REV-ERB axis controls expression of complement C4b expression and microglial synaptic phagoctyosis, providing a link between cellular circadian clock function and synaptic regulation.
    1. Cell Biology

    Proximity labeling identifies LOTUS domain proteins that promote the formation of perinuclear germ granules in C. elegans

    Ian F Price, Hannah L Hertz ... Wen Tang
    A proximity labeling approach defines germ granule proteome in Caenorhabditis elegans, and identifies LOTUS domain proteins as key regulators of germ granule assembly.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Universal and taxon-specific trends in protein sequences as a function of age

    Jennifer E James, Sara M Willis ... Joanna Masel
    Ancient protein domains remain shaped by amino acid availability during early life, while young animal proteins are shaped by a need for high intrinsic structural disorder.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Functional and structural segregation of overlapping helices in HIV-1

    Maliheh Safari, Bhargavi Jayaraman ... Alan D Frankel
    The HIV proteins Env and Rev encode helices that overlap in the viral genome but alternate in functional importance so that the non-functional surface of one helix encodes the functional surface of the other.
    1. Genetics and Genomics

    Variation in ubiquitin system genes creates substrate-specific effects on proteasomal protein degradation

    Mahlon A Collins, Gemechu Mekonnen, Frank Wolfgang Albert
    Genetic mapping reveals widespread, complex genetic effects on protein degradation by the ubiquitin-proteasome system, the primary protein degradation pathway in eukaryotic cells.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Globally defining the effects of mutations in a picornavirus capsid

    Florian Mattenberger, Victor Latorre ... Ron Geller
    Comprehensive analyses of how mutations in a picornavirus capsid affect viral fitness provide novel insights into viral biology, evolution, and host interactions.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    Boosting of cross-reactive antibodies to endemic coronaviruses by SARS-CoV-2 infection but not vaccination with stabilized spike

    Andrew R Crowley, Harini Natarajan ... Margaret E Ackerman
    Non-neutralizing antibodies to the SARS-CoV-2 spike protein’s S2 domain that also recognize widely circulating endemic coronavirus strains are rapidly boosted by natural infection but not vaccination with stabilized spike-based vaccines.

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