12 results found
    1. Physics of Living Systems
    2. Computational and Systems Biology

    Overall energy conversion efficiency of a photosynthetic vesicle

    Melih Sener, Johan Strumpfer ... Klaus Schulten
    The overall energy conversion efficiency is calculated for a bacterial vesicle that harvests solar energy for ATP production on the basis of an atomic-detail structural model.
    1. Structural Biology and Molecular Biophysics

    Absence of electron-transfer-associated changes in the time-dependent X-ray free-electron laser structures of the photosynthetic reaction center

    Gai Nishikawa, Yu Sugo ... Hiroshi Ishikita
    Revisiting limitations in time-resolved X-ray free-electron laser structures of the bacterial photosynthetic reaction center uncovers their irrelevance to proposed structural changes in electron transfer dynamics.
    1. Microbiology and Infectious Disease

    Contact-dependent killing by Caulobacter crescentus via cell surface-associated, glycine zipper proteins

    Leonor García-Bayona, Monica S Guo, Michael T Laub
    Genetic, biochemical, and cell biological approaches reveal a new form of contact-dependent inhibition in bacteria involving bacteriocin-like proteins that aggregate on the surface of cells.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    The Peptidisc, a simple method for stabilizing membrane proteins in detergent-free solution

    Michael Luke Carlson, John William Young ... Franck Duong
    A simple, yet elegant method for robust self-assembly of diverse membrane proteins into soluble peptide nanoparticles for their structural and functional analysis in detergent-free solutions.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Cellular assays identify barriers impeding iron-sulfur enzyme activity in a non-native prokaryotic host

    Francesca D'Angelo, Elena Fernández-Fueyo ... Gregory Bokinsky
    The intracellular network that distributes iron-sulfur clusters in bacteria is surprisingly 'plug and play' with iron-sulfur enzymes acquired from distantly related species, whereas the intracellular electron transfer network often needs plug adapters to connect with foreign enzymes.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    CRISPR-based functional genomics in human dendritic cells

    Marco Jost, Amy N Jacobson ... Jonathan S Weissman
    A CRISPR-based method enables targeted knockouts and genetic screens in human dendritic cells.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Coupling chemosensory array formation and localization

    Alejandra Alvarado, Andreas Kjær ... Simon Ringgaard
    Formation and cell pole-localization of chemotactic signaling-arrays is a coupled process mediated by ParP, which drives localized array-assembly and regulates the localization-dynamics of its network constituents.
    1. Structural Biology and Molecular Biophysics

    Structure of Mycobacterium tuberculosis cytochrome bcc in complex with Q203 and TB47, two anti-TB drug candidates

    Shan Zhou, Weiwei Wang ... Hongri Gong
    The three-dimensional structures of Mycobacterium tuberculosis cytochrome bcc in complex with the antituberculosis agents, Q203 and TB47, explain how these inhibitors suppress activity of the complex.
    1. Structural Biology and Molecular Biophysics
    2. Microbiology and Infectious Disease

    Regulation of signaling directionality revealed by 3D snapshots of a kinase:regulator complex in action

    Felipe Trajtenberg, Juan A Imelio ... Alejandro Buschiazzo
    The molecular mechanism of switching between phosphotransferase- and phosphatase-competent states in histidine-kinases has been uncovered, through direct crystallographic observation of bona fide complexes between a histidine-kinase and its response regulator from Bacillus subtilise.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    A composite double-/single-stranded RNA-binding region in protein Prp3 supports tri-snRNP stability and splicing

    Sunbin Liu, Sina Mozaffari-Jovin ... Markus C Wahl
    Structural and functional analyses show how the spliceosomal Prp3 protein concomitantly binds double- and single- stranded regions in U4/U6 di-snRNAs and serves to stabilize the U4/U6•U5 tri-snRNP for splicing.

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