841 results found
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Ribosome profiling of porcine reproductive and respiratory syndrome virus reveals novel features of viral gene expression

    Georgia M Cook, Katherine Brown ... Ian Brierley
    Combining ribosome profiling and RNA sequencing illuminates novel features of porcine reproductive and respiratory syndrome virus gene expression, including the regulation of polyprotein stoichiometry through temporal modulation of ribosomal frameshifting and the synthesis of non-canonical transcripts.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    A systematically-revised ribosome profiling method for bacteria reveals pauses at single-codon resolution

    Fuad Mohammad, Rachel Green, Allen R Buskirk
    With the removal of confounding artifacts, ribosome profiling can yield insight into the mechanism of protein synthesis in bacteria at high resolution.
    1. Cell Biology
    2. Evolutionary Biology

    Ribosome profiling reveals pervasive and regulated stop codon readthrough in Drosophila melanogaster

    Joshua G Dunn, Catherine K Foo ... Jonathan S Weissman
    Ribosomes translate through stop codons far more often than previously thought, yielding C-terminally extended proteins in a variety of eukaryotes.
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    Thousands of novel translated open reading frames in humans inferred by ribosome footprint profiling

    Anil Raj, Sidney H Wang ... Jonathan K Pritchard
    Over 7,000 novel translated sequences have been identified from human cells, including several hundred in annotated noncoding RNA, pseudogenes and de novo assembled transcripts.
    1. Microbiology and Infectious Disease

    Genome-wide regulatory dynamics of translation in the Plasmodium falciparum asexual blood stages

    Florence Caro, Vida Ahyong ... Joseph L DeRisi
    Ribosome profiling has bridged the knowledge gap between transcription and translation during malaria blood stage development and provided a comprehensive gene expression resource for this parasite.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    Many lncRNAs, 5’UTRs, and pseudogenes are translated and some are likely to express functional proteins

    Zhe Ji, Ruisheng Song ... Kevin Struhl
    Thousands of "noncoding" RNAs, 5' "untranslated" regions, and pseudogenes in humans are actually translated, and some of these are likely to express functional proteins.
    1. Biochemistry and Chemical Biology

    Translation of 5′ leaders is pervasive in genes resistant to eIF2 repression

    Dmitry E Andreev, Patrick BF O'Connor ... Pavel V Baranov
    Most of the mRNAs whose translation is resistant to the stress-induced repression of protein synthesis contain upstream open reading frames that are efficiently translated under normal conditions.
    1. Evolutionary Biology

    Long non-coding RNAs as a source of new peptides

    Jorge Ruiz-Orera, Xavier Messeguer ... M Mar Alba
    Ribosome profiling data from several eukaryotic species provides strong evidence that many long non-coding RNA molecules encode novel short proteins.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    METTL18-mediated histidine methylation of RPL3 modulates translation elongation for proteostasis maintenance

    Eriko Matsuura-Suzuki, Tadahiro Shimazu ... Shintaro Iwasaki
    METTL18 methylates histidine 245 of ribosomal protein RPL3, retards ribosome traversal at tyrosine codons, and thus ensures nascent protein folding for proteostasis maintenance.
    1. Cell Biology
    2. Computational and Systems Biology

    Concerted modification of nucleotides at functional centers of the ribosome revealed by single-molecule RNA modification profiling

    Andrew D Bailey, Jason Talkish ... Manuel Ares
    A method enabling identification of more than 100 RNA modifications in single ribosomal RNA molecules uncovers new classes of modified ribosomes.

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