14,559 results found
    1. Developmental Biology
    2. Medicine

    RAB23 coordinates early osteogenesis by repressing FGF10-pERK1/2 and GLI1

    Md Rakibul Hasan, Maarit Takatalo ... David PC Rice
    RAB23 regulates calvarial bone and suture development both independently through, and by cross-talk between, Hedgehog and fibroblast growth factor signaling.
    1. Cell Biology
    2. Neuroscience

    RNG105/caprin1, an RNA granule protein for dendritic mRNA localization, is essential for long-term memory formation

    Kei Nakayama, Rie Ohashi ... Nobuyuki Shiina
    The formation of long-term memory in mice requires an element of RNA granules that localizes messenger RNAs to dendrites.
    1. Evolutionary Biology
    2. Genetics and Genomics

    A variant-centric perspective on geographic patterns of human allele frequency variation

    Arjun Biddanda, Daniel P Rice, John Novembre
    New tools for visualizing population genetic data can provide a more direct understanding of levels of differentiation among human populations.
    1. Medicine
    2. Neuroscience

    The mechanism underlying transient weakness in myotonia congenita

    Jessica H Myers, Kirsten Denman ... Mark M Rich
    Transient weakness in myotonia congenita is caused by depolarization secondary to activation of persistent Na+ current in skeletal muscle.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    A tethered delivery mechanism explains the catalytic action of a microtubule polymerase

    Pelin Ayaz, Sarah Munyoki ... Luke M Rice
    Using linked TOG domains that each bind a curved conformation of αβ-tubulin, a microtubule polymerase catalyzes fast elongation by concentrating αβ-tubulin near the polymer end.
    1. Chromosomes and Gene Expression

    Epigenetic memory independent of symmetric histone inheritance

    Daniel S Saxton, Jasper Rine
    Reduced fidelity of histone inheritance has minimal effects on inheritance of epigenetic states of heterochromatin in Saccharomyces..
    1. Computational and Systems Biology

    Automated, high-dimensional evaluation of physiological aging and resilience in outbred mice

    Zhenghao Chen, Anil Raj ... Adam Freund
    A non-invasive animal monitoring system paired with a custom analysis pipeline allows organism-level aging to be studied with improved throughput, resolution, and physiological scope while reducing the activation energy that comes with highly specialized challenge-based procedures.
    1. Medicine
    2. Neuroscience

    The role of action potential changes in depolarization-induced failure of excitation contraction coupling in mouse skeletal muscle

    Xueyong Wang, Murad Nawaz ... Mark M Rich
    Detailed studies of excitation contraction coupling allowed determination of quantitative relationships between resting potential, generation of action potentials, conduction of action potentials, and generation of Ca2+ transients in individual mouse skeletal muscle fibers.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Distinguishing between recruitment and spread of silent chromatin structures in Saccharomyces cerevisiae

    Molly Brothers, Jasper Rine
    Heterochromatin proteins like the SIR complex in budding yeast use different mechanisms for recruitment to nucleation sites and long-range spread to create a domain of transcriptional silencing.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    A mutation uncouples the tubulin conformational and GTPase cycles, revealing allosteric control of microtubule dynamics

    Elisabeth A Geyer, Alexander Burns ... Luke M Rice
    A buried mutation in αβ-tubulin reveals an allosteric response to GDP in the lattice that dictates microtubule catastrophe and shrinking.

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