2,609 results found
    1. Chromosomes and Gene Expression
    2. Computational and Systems Biology

    Transcriptome maps of general eukaryotic RNA degradation factors

    Salma Sohrabi-Jahromi, Katharina B Hofmann ... Patrick Cramer
    Mapping of 30 general RNA degradation factors onto the yeast transcriptome provides the global distribution of factors for RNA turnover and surveillance in a eukaryotic cell.
    1. Chromosomes and Gene Expression
    2. Microbiology and Infectious Disease

    Changes in mRNA abundance drive shuttling of RNA binding proteins, linking cytoplasmic RNA degradation to transcription

    Sarah Gilbertson, Joel D Federspiel ... Britt Glaunsinger
    Messenger RNA degradation alters protein trafficking to control transcription.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    A conserved RNA degradation complex required for spreading and epigenetic inheritance of heterochromatin

    Gergana Shipkovenska, Alexander Durango ... Danesh Moazed
    Genetic and biochemical studies show that a conserved ribosome biogenesis complex also localizes to heterochromatin, where it triggers RNA degradation and promotes the spreading and epigenetic inheritance of histone methylation.
    1. Chromosomes and Gene Expression
    2. Stem Cells and Regenerative Medicine

    Decoupling the impact of microRNAs on translational repression versus RNA degradation in embryonic stem cells

    Jacob W Freimer, TJ Hu, Robert Blelloch
    The deletion of Ddx6 results in the translational upregulation, but not transcript stabilization, of microRNA targets in embryonic stem cells while largely phenocopying the overall impact of global microRNA loss.
    1. Microbiology and Infectious Disease

    A dedicated diribonuclease resolves a key bottleneck for the terminal step of RNA degradation

    Soo-Kyoung Kim, Justin D Lormand ... Vincent T Lee
    RNA degradation is completed through specific intermediates, such as diribonucleotides, which must be removed from the cells by a specific enzyme.
    1. Cell Biology

    Autophagy-dependent ribosomal RNA degradation is essential for maintaining nucleotide homeostasis during C. elegans development

    Yubing Liu, Wei Zou ... Xiaochen Wang
    Embryonic development requires autophagy-dependent degradation of ribosomal RNAs.
    1. Cell Biology

    Macrophage inflammation resolution requires CPEB4-directed offsetting of mRNA degradation

    Clara Suñer, Annarita Sibilio ... Raúl Méndez
    Decay rate of mRNAs encoding inflammatory regulators is controlled by the balance between AU-rich element-mediated deadenylation and cytoplasmic polyadenylation element-mediated polyadenylation.
    1. Cell Biology

    Spatial organization shapes the turnover of a bacterial transcriptome

    Jeffrey R Moffitt, Shristi Pandey ... Xiaowei Zhuang
    Transcriptome-scale RNA imaging and lifetime measurements reveal that the E. coli transcriptome is spatially organized and that this organization modulates the post-transcriptional fate of bacterial mRNAs.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    RNA structures that resist degradation by Xrn1 produce a pathogenic Dengue virus RNA

    Erich G Chapman, Stephanie L Moon ... Jeffrey S Kieft
    The Dengue virus contains discretely folded RNA structures that confer the ability to resist a powerful host cell enzyme and produce a disease-inducing noncoding RNA.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Structural characterization of NrnC identifies unifying features of dinucleases

    Justin D Lormand, Soo-Kyoung Kim ... Holger Sondermann
    Dinucleases, specialized enzymes that catalyze the final step in RNA degradation, have evolved independently and repeatedly to fulfill essential roles in cell growth.

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