3,661 results found
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    RNA localization mechanisms transcend cell morphology

    Raeann Goering, Ankita Arora ... J Matthew Taliaferro
    Mechanisms that regulate RNA localization in one cell type predictably regulate RNA localization in other cell types, even if they have vastly different morphologies, implying an underlying regulatory code that cuts across specific subcellular structures.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    FMRP promotes RNA localization to neuronal projections through interactions between its RGG domain and G-quadruplex RNA sequences

    Raeann Goering, Laura I Hudish ... J Matthew Taliaferro
    The molecular determinants for neuronal subcellular RNA transport by FMRP are defined, with interactions between RNA G-quadruplexes and the RGG domain of FMRP being of critical importance.
    1. Cell Biology
    2. Neuroscience

    RNG105/caprin1, an RNA granule protein for dendritic mRNA localization, is essential for long-term memory formation

    Kei Nakayama, Rie Ohashi ... Nobuyuki Shiina
    The formation of long-term memory in mice requires an element of RNA granules that localizes messenger RNAs to dendrites.
    1. Developmental Biology
    2. Genetics and Genomics

    Systematic imaging reveals features and changing localization of mRNAs in Drosophila development

    Helena Jambor, Vineeth Surendranath ... Pavel Tomancak
    Genome wide analysis reveals that many transcripts are localized in cells of the ovary and that the localization status of mRNAs changes over time and in different cell types.
    1. Cell Biology
    2. Neuroscience

    Free circular introns with an unusual branchpoint in neuronal projections

    Harleen Saini, Alicia A Bicknell ... Melissa J Moore
    A systematic study of RNA localization unexpectedly finds a set of free circular introns with a non-canonical C branchpoint enriched in neuronal projections.
    1. Developmental Biology

    An essential role for maternal control of Nodal signaling

    Pooja Kumari, Patrick C Gilligan ... Karuna Sampath
    Regulation of conserved Nodal factors by a maternal protein ensures that Nodal signaling is repressed until the appropriate time in embryonic development.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    HBO1-MLL interaction promotes AF4/ENL/P-TEFb-mediated leukemogenesis

    Satoshi Takahashi, Akinori Kanai ... Akihiko Yokoyama
    Interaction of the MLL and HBO1 complexes is a key nexus for leukemic transformation that can serve as a therapeutic target.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Live-cell mapping of organelle-associated RNAs via proximity biotinylation combined with protein-RNA crosslinking

    Pornchai Kaewsapsak, David Michael Shechner ... Alice Y Ting
    Live-cell nanometer-resolution RNA labeling method enables transcriptome-wide mapping of endogenous RNAs in nuclear, cytosol, ER, and mitochondrial subcompartments.
    1. Cell Biology
    2. Neuroscience

    Matrin 3-dependent neurotoxicity is modified by nucleic acid binding and nucleocytoplasmic localization

    Ahmed M Malik, Roberto A Miguez ... Sami J Barmada
    The deposition of Matrin 3, a DNA/RNA binding protein implicated in ALS and FTD, results in neurodegeneration dependent upon its localization, self-association, and ability to bind nucleic acids.
    1. Cell Biology
    2. Developmental Biology

    Decoding the IGF1 signaling gene regulatory network behind alveologenesis from a mouse model of bronchopulmonary dysplasia

    Feng Gao, Changgong Li ... Parviz Minoo
    Publicly available gene expression data and proven methodologies for building model Gene Regulatory Networks are applied to successfully construct the IGF1 signaling GRN behind alveologenesis, serving as a pioneer in transforming how lung development and its associated diseases is approached.

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