1,045 results found
    1. Chromosomes and Gene Expression

    Monoallelically expressed noncoding RNAs form nucleolar territories on NOR-containing chromosomes and regulate rRNA expression

    Qinyu Hao, Minxue Liu ... Kannanganattu V Prasanth
    A novel family of nucleolus-enriched ncRNAs forms allele-specific territories on the nucleolar organizing region (NOR)-containing acrocentric chromosomes.
    1. Microbiology and Infectious Disease

    Ribosomal RNA (rRNA) sequences from 33 globally distributed mosquito species for improved metagenomics and species identification

    Cassandra Koh, Lionel Frangeul ... Maria-Carla Saleh
    A score-based read selection strategy enables the assembly of novel full-length ribosomal RNA sequences for mosquitoes, which improves the physical and computational removal of interfering ribosomal RNA reads in RNA-seq and provides another molecular marker for taxonomic and phylogenetic inquiries.
    1. Biochemistry and Chemical Biology

    Tetramerisation of the CRISPR ring nuclease Crn3/Csx3 facilitates cyclic oligoadenylate cleavage

    Januka S Athukoralage, Stuart McQuarrie ... Malcolm F White
    A widespread ribonuclease is a CRISPR-associated ring nuclease with a highly unusual cooperative mechanism involving tetramerisation of the enzyme.
    1. Cell Biology
    2. Immunology and Inflammation

    RTN3 inhibits RIG-I-mediated antiviral responses by impairing TRIM25-mediated K63-linked polyubiquitination

    Ziwei Yang, Jun Wang ... Ersheng Kuang
    RTN3 is upregulated upon RNA viral infection, in turn suppresses antiviral responses by impairing TRIM25-mediated RIG-I K63-linked polyubiquitination and decreases neutrophil populations and inflammatory infiltration, representing a novel inflammatory resolution.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Full length RTN3 regulates turnover of tubular endoplasmic reticulum via selective autophagy

    Paolo Grumati, Giulio Morozzi ... Ivan Dikic
    Full length RTN3 homodimerization mediates ER tubules fragmentation and their subsequent delivery to lysosome.
    1. Chromosomes and Gene Expression

    The dynamic assembly of distinct RNA polymerase I complexes modulates rDNA transcription

    Eva Torreira, Jaime Alegrio Louro ... Carlos Fernández-Tornero
    Live-cell imaging, genetic analysis and electron cryomicroscopy identify structural motifs involved in the differential assembly of Pol I-Rrn3 complexes and Pol I homodimers in response to nutrient availability.
    1. Chromosomes and Gene Expression

    Translational initiation in E. coli occurs at the correct sites genome-wide in the absence of mRNA-rRNA base-pairing

    Kazuki Saito, Rachel Green, Allen R Buskirk
    E. coli ribosomes incapable of base-pairing with the Shine-Dalgarno sequence are still selective for annotated start sites, indicating these sites are hard-wired for initiation by other mRNA features.
    1. Cell Biology
    2. Computational and Systems Biology

    Age-dependent aggregation of ribosomal RNA-binding proteins links deterioration in chromatin stability with challenges to proteostasis

    Julie Paxman, Zhen Zhou ... Nan Hao
    The interaction between rDNA instability and proteostasis stress, two major aging hallmarks, underlies single-cell aging trajectories in yeast.
    1. Structural Biology and Molecular Biophysics

    Structural and mechanistic insights into ribosomal ITS2 RNA processing by nuclease-kinase machinery

    Jiyun Chen, Hong Chen ... Liang Liu
    The structures of full-length Las1-Grc3 complexes provide crucial insights into the activation mechanism of HEPN nuclease and the pathway of pre-rRNA processing in ribosome biosynthesis.
    1. Structural Biology and Molecular Biophysics

    Structural mechanism of ATP-independent transcription initiation by RNA polymerase I

    Yan Han, Chunli Yan ... Yuan He
    Structures of RNA polymerase I transcription machinery revealed a ratcheting motion within the complex in coordination with three distinct functional states, implicating a novel mechanism for promoter bubble opening in the absence of ATP hydrolysis.

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