Milo S Johnson, Shreyas Gopalakrishnan ... Michael M Desai
Experimentally evolved yeast populations increase in fitness predictably but do not divide into coexisting lineages or dramatically increase their mutation rates after 10,000 generations.
Telomere length is linked to DNA replication, and we found excessive telomeric origin firing caused by several distinct mutants did not lengthen telomeres, narrowing possible mechanisms.
Heterochromatin proteins like the SIR complex in budding yeast use different mechanisms for recruitment to nucleation sites and long-range spread to create a domain of transcriptional silencing.
Felix Proulx-Giraldeau, Jan M Skotheim, Paul François
An evolutionary algorithm is used to build gene networks implementing cell size control, and suggests multiple ways for evolution to first build sizers and turn them into adders depending on evolutionary constraints.
Gautam Susarla, Priyanka Kataria ... Patrick D'Silva
Yeast DJ-1 homologs are molecular erasers of glycation adducts on cellular macromolecules and preserve mitochondrial health through redistributing into mitochondria under elevated carbonyl stress.
Implementation and characterisation of plasma-focused ion beams for volumetric imaging of cryogenically preserved cells and tissues for ultrastructural examination in their native state.
Comprehensive mutational scanning of the SARS-CoV-2 protease, Mpro, provides functional and structural information to aid in the design of more effective inhibitors against the protease with reduced potential of evolving viral resistance.