1,324 results found
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Distinct roles for S. cerevisiae H2A copies in recombination and repeat stability, with a role for H2A.1 threonine 126

    Nealia CM House, Erica J Polleys ... Catherine H Freudenreich
    Despite differing by only one amino acid in the C-terminal tail, copy 1 of yeast histone 2A has a repair-specific role not shared by copy 2.
    1. Evolutionary Biology

    Phenotypic and molecular evolution across 10,000 generations in laboratory budding yeast populations

    Milo S Johnson, Shreyas Gopalakrishnan ... Michael M Desai
    Experimentally evolved yeast populations increase in fitness predictably but do not divide into coexisting lineages or dramatically increase their mutation rates after 10,000 generations.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    The role of Rif1 in telomere length regulation is separable from its role in origin firing

    Calla B Shubin, Carol W Greider
    Telomere length is linked to DNA replication, and we found excessive telomeric origin firing caused by several distinct mutants did not lengthen telomeres, narrowing possible mechanisms.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Distinguishing between recruitment and spread of silent chromatin structures in Saccharomyces cerevisiae

    Molly Brothers, Jasper Rine
    Heterochromatin proteins like the SIR complex in budding yeast use different mechanisms for recruitment to nucleation sites and long-range spread to create a domain of transcriptional silencing.
    1. Computational and Systems Biology

    Evolution of cell size control is canalized towards adders or sizers by cell cycle structure and selective pressures

    Felix Proulx-Giraldeau, Jan M Skotheim, Paul François
    An evolutionary algorithm is used to build gene networks implementing cell size control, and suggests multiple ways for evolution to first build sizers and turn them into adders depending on evolutionary constraints.
    1. Biochemistry and Chemical Biology

    Saccharomyces cerevisiae DJ-1 paralogs maintain genome integrity through glycation repair of nucleic acids and proteins

    Gautam Susarla, Priyanka Kataria ... Patrick D'Silva
    Yeast DJ-1 homologs are molecular erasers of glycation adducts on cellular macromolecules and preserve mitochondrial health through redistributing into mitochondria under elevated carbonyl stress.
    1. Cell Biology
    2. Chromosomes and Gene Expression

    No current evidence for widespread dosage compensation in S. cerevisiae

    Eduardo M Torres, Michael Springer, Angelika Amon
    Dosage compensation does not take place in wild yeast strains.
    1. Cell Biology

    Cryo-plasma FIB/SEM volume imaging of biological specimens

    Maud Dumoux, Thomas Glen ... Michael Grange
    Implementation and characterisation of plasma-focused ion beams for volumetric imaging of cryogenically preserved cells and tissues for ultrastructural examination in their native state.
    1. Chromosomes and Gene Expression
    2. Genetics and Genomics

    Identification of 1600 replication origins in S. cerevisiae

    Eric J Foss, Carmina Lichauco ... Antonio Bedalov
    Replication origins in yeast are more widespread than previously believed.
    1. Evolutionary Biology
    2. Microbiology and Infectious Disease

    Comprehensive fitness landscape of SARS-CoV-2 Mpro reveals insights into viral resistance mechanisms

    Julia M Flynn, Neha Samant ... Daniel NA Bolon
    Comprehensive mutational scanning of the SARS-CoV-2 protease, Mpro, provides functional and structural information to aid in the design of more effective inhibitors against the protease with reduced potential of evolving viral resistance.

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