823 results found
    1. Biochemistry and Chemical Biology

    A secretory pathway kinase regulates sarcoplasmic reticulum Ca2+ homeostasis and protects against heart failure

    Adam J Pollak, Canzhao Liu ... Jack E Dixon
    Protein phosphorylation within the lumen of the secretory pathway regulates cardiac function.
    1. Plant Biology

    The biogenesis of CLEL peptides involves several processing events in consecutive compartments of the secretory pathway

    Nils Stührwohldt, Stefan Scholl ... Andreas Schaller
    Step-wise processing of plant peptide hormone precursors by subtilisin-like proteinases in consecutive compartments of the secretory pathway is required for formation and secretion of the bioactive peptides.
    1. Cell Biology

    The metal transporter ZIP13 supplies iron into the secretory pathway in Drosophila melanogaster

    Guiran Xiao, Zhihui Wan ... Bing Zhou
    Drosophila ZIP13 (Slc39a13), a presumed zinc importer, is responsible for iron delivery to the secretory pathway.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Pathogenic variants of sphingomyelin synthase SMS2 disrupt lipid landscapes in the secretory pathway

    Tolulope Sokoya, Jan Parolek ... Joost CM Holthuis
    Organellar lipidomics and lipid reporter studies in intact cells reveal how disease-relevant mutations in a sphingolipid biosynthetic enzyme cause a wide-ranging perturbation of lipid distributions and membrane properties along the secretory pathway.
    1. Biochemistry and Chemical Biology

    A secretory kinase complex regulates extracellular protein phosphorylation

    Jixin Cui, Junyu Xiao ... Jack E Dixon
    A pseudokinase in the secretory pathway, Fam20A, activates the real Golgi casein kinase, Fam20C, via a unique mechanism that is lost in human diseases.
    1. Cell Biology

    COPI selectively drives maturation of the early Golgi

    Effrosyni Papanikou, Kasey J Day ... Benjamin S Glick
    Inactivation of the COPI vesicle coat in yeast reveals that COPI recycles early but not late Golgi proteins.
    1. Cell Biology

    Functional hierarchy among different Rab27 effectors involved in secretory granule exocytosis

    Kunli Zhao, Kohichi Matsunaga ... Tetsuro Izumi
    TIRF microscopy in living pancreatic beta cells lacking one or two of Rab27 effectors and the exocyst components reveals how each molecule functions in sequence or in parallel in multiple redundant paths and rate-limiting processes in granule exocytosis.
    1. Cell Biology

    A stress assembly that confers cell viability by preserving ERES components during amino-acid starvation

    Margarita Zacharogianni, Angelica Aguilera-Gomez ... Catherine Rabouille
    Amino-acid starvation leads to the formation of a reversible stress assembly, the Sec body, which is a pro-survival reservoir for components of the ER exit sites.
    1. Cell Biology

    Misfolded GPI-anchored proteins are escorted through the secretory pathway by ER-derived factors

    Eszter Zavodszky, Ramanujan S Hegde
    ER-resident chaperones and cargo receptors make excursions to the cell surface and endocytic compartments when they accompany misfolded clients to lysosomes for degradation.
    1. Neuroscience

    The GTPase Rab26 links synaptic vesicles to the autophagy pathway

    Beyenech Binotti, Nathan J Pavlos ... Reinhard Jahn
    Rab26 selectively directs synaptic and secretory vesicles into preautophagosomal structures, suggesting the presence of a novel pathway (vesiculophagy) for degradation of synaptic vesicles.

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