909 results found
    1. Plant Biology

    Fluctuations of the transcription factor ATML1 generate the pattern of giant cells in the Arabidopsis sepal

    Heather M Meyer, José Teles ... Adrienne H K Roeder
    Fluctuations of a transcription factor that coincide with the G2 phase of the cell cycle pattern two interspersed cell fates in a multicellular system.
    1. Cell Biology

    Orderly assembly underpinning built-in asymmetry in the yeast centrosome duplication cycle requires cyclin-dependent kinase

    Marco Geymonat, Qiuran Peng ... Marisa Segal
    The polarized orientation of the mitotic spindle in budding yeast arises from spindle pole structural and functional asymmetry subject to cell cycle control.
    1. Developmental Biology
    2. Neuroscience

    Transcriptional profiling of sequentially generated septal neuron fates

    Miguel Turrero García, Sarah K Stegmann ... Corey C Harwell
    A combination of single-cell RNA sequencing of the developing septum and genetic fate mapping is used to analyze the origin of septal neurons.
    1. Epidemiology and Global Health

    Prediction of type 2 diabetes mellitus onset using logistic regression-based scorecards

    Yochai Edlitz, Eran Segal
    Computational methods were used to develop accurate manual scorecards for early detection of participants at risk of type 2 diabetes based on the UK Biobank database.
    1. Evolutionary Biology
    2. Immunology and Inflammation

    Evolution of pathogen tolerance and emerging infections: A missing experimental paradigm

    Srijan Seal, Guha Dharmarajan, Imroze Khan
    An integrated empirical paradigm tracing immune strategies, underlying mechanisms and infection outcomes across reservoir host-pathogen systems, their specific ecological contexts, life-history features, and coevolutionary dynamics can reveal the actual patterns and processes underlying spillover in the wild.
    1. Microbiology and Infectious Disease

    Septal secretion of protein A in Staphylococcus aureus requires SecA and lipoteichoic acid synthesis

    Wenqi Yu, Dominique Missiakas, Olaf Schneewind
    Surface protein precursors traffic to lipoteichoic acid-rich septal membranes of Staphylococcus aureus for cleavage of their YSIRK-GXXS motif signal peptides and SecA-mediated translocation across the plasma membrane.
    1. Neuroscience

    AANAT1 functions in astrocytes to regulate sleep homeostasis

    Sejal Davla, Gregory Artiushin ... Donald J van Meyel
    Drosophila astrocytes regulate the homeostatic response to sleep need and express the AANAT1 enzyme that limits brain accumulation of serotonin and dopamine caused by overnight sleep deprivation.
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    1. Neuroscience

    Analysis of the immune response to sciatic nerve injury identifies efferocytosis as a key mechanism of nerve debridement

    Ashley L Kalinski, Choya Yoon ... Roman J Giger
    In the injured sciatic nerve, blood-derived monocytes and macrophages eat dying leukocytes, thereby contributing to nerve debridement and inflammation resolution, and this correlates with neuronal regeneration.
    1. Neuroscience

    Somatostatin-positive interneurons in the dentate gyrus of mice provide local- and long-range septal synaptic inhibition

    Mei Yuan, Thomas Meyer ... Marlene Bartos
    Somatostatin-expressing interneurons of the rodent dentate gyrus fall into at least two functionally distinct interneuron types with different synaptic integrations into the local dentate gyrus and the more distant medial septum neuronal network.

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