10 results found
    1. Cell Biology
    2. Developmental Biology

    tRNA synthetase counteracts c-Myc to develop functional vasculature

    Yi Shi, Xiaoling Xu ... Xiang-Lei Yang
    In addition to its cytoplasmic role for translation, the seryl-tRNA synthetase also antagonizes the c-Myc transcription factor in the nucleus to transcriptionally repress the growth factor VEGFA and ensure proper development of the vasculature in vertebrates.
    1. Evolutionary Biology

    The birth of a bacterial tRNA gene by large-scale, tandem duplication events

    Gökçe B Ayan, Hye Jin Park, Jenna Gallie
    A bacterial tRNA gene set rapidly evolves, compensating the loss of one tRNA type by large duplication events that increase the gene copy number of a second, different tRNA type.
    1. Microbiology and Infectious Disease

    Plasmodium falciparum adapts its investment into replication versus transmission according to the host environment

    Abdirahman I Abdi, Fiona Achcar ... Matthias Marti
    We investigate how parasites adapt to environmental changes in the context of changing transmission patterns, for example by increasing investment in transmission stages at low endemicity such as elimination settings.
    1. Computational and Systems Biology
    2. Genetics and Genomics

    A computational screen for alternative genetic codes in over 250,000 genomes

    Yekaterina Shulgina, Sean R Eddy
    Five previously unknown alternative genetic codes are found in a screen of bacterial and archaeal genomes by a new computational method called Codetta, lending new insights into the process of their evolution.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Cap-proximal nucleotides via differential eIF4E binding and alternative promoter usage mediate translational response to energy stress

    Ana Tamarkin-Ben-Harush, Jean-Jacques Vasseur ... Rivka Dikstein
    Differential eIF4E binding to transcription initiation nucleotides and alternative promoter usage of eIF1A, PABP and other genes are involved in the response of the translation machinery to energy stress.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Mechanism of B-box 2 domain-mediated higher-order assembly of the retroviral restriction factor TRIM5α

    Jonathan M Wagner, Marcin D Roganowicz ... Owen Pornillos
    Higher-order assembly enables and links pathogen recognition and downstream steps in the TRIM5-mediated anti-HIV response.
    1. Microbiology and Infectious Disease

    The antigenic switching network of Plasmodium falciparum and its implications for the immuno-epidemiology of malaria

    Robert Noble, Zóe Christodoulou ... Mario Recker
    The first comprehensive analysis of antigenic switching in the malaria-causing parasite Plasmodium falciparum provides new insights into the process that prevents individuals from acquiring immunity to the disease.
    1. Structural Biology and Molecular Biophysics

    Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21

    Claire Dickson, Adam J Fletcher ... Leo C James
    Phosphorylation deactivates TRIM21 B Box autoinhibition to licence proinflammatory signalling by cytosolic antibodies.
    1. Microbiology and Infectious Disease

    A coordinated transcriptional switching network mediates antigenic variation of human malaria parasites

    Xu Zhang, Francesca Florini ... Kirk W Deitsch
    Malaria parasites avoid destruction by their host's immune response through systematic and coordinated expression switching between members of a network of variant antigen-encoding genes, a process that is mediated by a uniquely conserved gene called var2csa.
    1. Structural Biology and Molecular Biophysics

    Cryo-EM of dynein microtubule-binding domains shows how an axonemal dynein distorts the microtubule

    Samuel E Lacey, Shaoda He ... Andrew P Carter
    Relion was used to solve structures of microtubules decorated with dynein microtubule-binding domains revealing that an axonemal dynein distorts the microtubule cross-sectional curvature.

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