In addition to its cytoplasmic role for translation, the seryl-tRNA synthetase also antagonizes the c-Myc transcription factor in the nucleus to transcriptionally repress the growth factor VEGFA and ensure proper development of the vasculature in vertebrates.
A bacterial tRNA gene set rapidly evolves, compensating the loss of one tRNA type by large duplication events that increase the gene copy number of a second, different tRNA type.
Abdirahman I Abdi, Fiona Achcar ... Matthias Marti
We investigate how parasites adapt to environmental changes in the context of changing transmission patterns, for example by increasing investment in transmission stages at low endemicity such as elimination settings.
Five previously unknown alternative genetic codes are found in a screen of bacterial and archaeal genomes by a new computational method called Codetta, lending new insights into the process of their evolution.
Ana Tamarkin-Ben-Harush, Jean-Jacques Vasseur ... Rivka Dikstein
Differential eIF4E binding to transcription initiation nucleotides and alternative promoter usage of eIF1A, PABP and other genes are involved in the response of the translation machinery to energy stress.
The first comprehensive analysis of antigenic switching in the malaria-causing parasite Plasmodium falciparum provides new insights into the process that prevents individuals from acquiring immunity to the disease.
Malaria parasites avoid destruction by their host's immune response through systematic and coordinated expression switching between members of a network of variant antigen-encoding genes, a process that is mediated by a uniquely conserved gene called var2csa.
Relion was used to solve structures of microtubules decorated with dynein microtubule-binding domains revealing that an axonemal dynein distorts the microtubule cross-sectional curvature.