4,046 results found
    1. Developmental Biology
    2. Neuroscience

    Phosphodiesterase 4D acts downstream of Neuropilin to control Hedgehog signal transduction and the growth of medulloblastoma

    Xuecai Ge, Ljiljana Milenkovic ... Matthew P Scott
    Neuropilin integrates with Hedgehog signal transduction by a newly identified transducer to control cerebellar neurogenesis and medulloblastoma.
    1. Cell Biology

    Regulation of EGFR signal transduction by analogue-to-digital conversion in endosomes

    Roberto Villaseñor, Hidenori Nonaka ... Marino Zerial
    Cells package active receptors in endosomes at fairly constant amounts and can determine different cell-fate decisions by regulating the number and lifetime of receptor packages.
    1. Plant Biology

    Calcium specificity signaling mechanisms in abscisic acid signal transduction in Arabidopsis guard cells

    Benjamin Brandt, Shintaro Munemasa ... Julian I Schroeder
    The calcium-dependent signaling pathway during ABA-dependent stomatal closure requires the calcium-independent pathway, and calcium signaling specificity is mediated by PP2C protein phosphatases.
    1. Biochemistry and Chemical Biology

    Allosteric mechanism of signal transduction in the two-component system histidine kinase PhoQ

    Bruk Mensa, Nicholas F Polizzi ... William F DeGrado
    Mutations along the signaling pathway of the E. coli sensor histidine kinase PhoQ alter signal gain and ligand-sensitivity by altering thermodynamic allosteric coupling between domains.
    1. Structural Biology and Molecular Biophysics

    Limited dishevelled/Axin oligomerization determines efficiency of Wnt/β-catenin signal transduction

    Wei Kan, Michael D Enos ... William I Weis
    In vitro and in cellulo characterization of oligomerization by the cytoplasmic Wnt effector dishevelled and its partner Axin provide new mechanistic principles for Wnt/β-catenin signaling.
    1. Cell Biology
    2. Computational and Systems Biology

    Akt phosphorylates insulin receptor substrate to limit PI3K-mediated PIP3 synthesis

    Alison L Kearney, Dougall M Norris ... James G Burchfield
    Akt phosphorylates insulin receptor substrate to engage negative feedback and limit signal propagation.
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    The insulin receptor cellular IRES confers resistance to eIF4A inhibition

    Calla M Olson, Marissa R Donovan ... Michael T Marr II
    Utilizing a conserved mechanism, a ribosome can initiate translation from a site within the insulin receptor mRNA to maintain protein synthesis even when standard mechanisms of initiating translation have been inhibited by stress.
    1. Cell Biology
    2. Computational and Systems Biology

    Limits on information transduction through amplitude and frequency regulation of transcription factor activity

    Anders S Hansen, Erin K O'Shea
    The ability of cells to transmit information encoded in signaling dynamics is fundamentally limited by the gene decoding step.
    1. Cell Biology

    Cavin-3 dictates the balance between ERK and Akt signaling

    Victor J Hernandez, Jian Weng ... Peter Michaely
    Cavin-3 is a tumor suppressor protein that inhibits Akt signaling, suppresses Warburg metabolism, promotes apoptosis, and protects against cachexia.
    1. Plant Biology

    Correction: Calcium specificity signaling mechanisms in abscisic acid signal transduction in Arabidopsis guard cells

    Benjamin Brandt, Shintaro Munemasa ... Julian I Schroeder

Refine your results by:

Type
Research categories