5,781 results found
    1. Neuroscience

    Single-cell transcriptomes of developing and adult olfactory receptor neurons in Drosophila

    Colleen N McLaughlin, Maria Brbić ... Hongjie Li
    Single-cell transcriptomes of olfactory receptor neurons at multiple developmental stages reveal cell-type-specific gene expression programs that underlie their development and sensory biology.
    1. Neuroscience

    Temporal evolution of single-cell transcriptomes of Drosophila olfactory projection neurons

    Qijing Xie, Maria Brbic ... Hongjie Li
    Single-cell transcriptomes of Drosophila olfactory projection neurons correspond to previously defined cell types, exhibit unique characteristics at different developmental stages, and reveal cell-type-specific gene expression programs in development and function.
    1. Genetics and Genomics
    2. Neuroscience

    A single-cell transcriptomic and anatomic atlas of mouse dorsal raphe Pet1 neurons

    Benjamin W Okaty, Nikita Sturrock ... Susan M Dymecki
    Dorsal raphe Pet1 neurons are molecularly heterogeneous, comprising as many as fourteen distinct subtypes that show biased cell body distributions across dorsal raphe subdomains.
    1. Neuroscience

    Single-nucleus transcriptomic analysis of human dorsal root ganglion neurons

    Minh Q Nguyen, Lars J von Buchholtz ... Steve Davidson
    Single-nucleus transcriptomics exposes unique features of human somatosensory neurons and clues that may help resolve repeated problems in translating new experimental approaches for treating pain.
    1. Neuroscience

    High-throughput mapping of single-neuron projection and molecular features by retrograde barcoded labeling

    Peibo Xu, Jian Peng ... Yuejun Chen
    A multiplexed retrograde virus tracing method captures single-neuron projectome and transcriptome simultaneously.
    1. Neuroscience

    Single-cell transcriptomes and whole-brain projections of serotonin neurons in the mouse dorsal and median raphe nuclei

    Jing Ren, Alina Isakova ... Liqun Luo
    The combination of single-cell transcriptomics and whole-brain mapping of bulk and single-cell projections reveals the relationship between the molecular architecture, cell body distribution, and axonal arborization of serotonin neurons.
    1. Neuroscience

    Transcriptional profiling at whole population and single cell levels reveals somatosensory neuron molecular diversity

    Isaac M Chiu, Lee B Barrett ... Clifford J Woolf
    Molecular analysis paints a detailed picture of the distinctiveness and complexities of peripheral somatosensory neurons.
    1. Genetics and Genomics
    2. Neuroscience

    Single-cell transcriptome profiles of Drosophila fruitless-expressing neurons from both sexes

    Colleen M Palmateer, Catherina Artikis ... Michelle N Arbeitman
    A single-cell RNA-seq study examining gene expression profiles in neurons that underlie Drosophila reproductive behaviors shows males and females build sex-specific behaviors at the molecular-genetic level by overlaying sex-specific information on core gene expression networks.
    1. Neuroscience

    Subcellular sequencing of single neurons reveals the dendritic transcriptome of GABAergic interneurons

    Julio D Perez, Susanne tom Dieck ... Erin M Schuman
    Single somata and dendrites of individual rat neurons were laser-captured and sequenced to discover and compare the subcellular transcriptomes, identifying over 4000 mRNAs in GABAergic dendrites.
    1. Neuroscience

    Functional interactions among neurons within single columns of macaque V1

    Ethan B Trepka, Shude Zhu ... Tirin Moore
    A proof-of-principle is provided for the use of high-density neurophysiological recordings in assessing local circuit interactions within the macaque brain.

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