A single night of sleep deprivation suppresses fighting behaviors in male fruit flies, with consequent impairments in reproductive fitness.

The temperature-sensitive protein CIRBP contributes to the effect of sleep loss on the molecular circadian clock.

The loss of neuronal connectivity in a brain region called the hippocampus significantly contributes to the cognitive impairments associated with sleep deprivation.

Multi-modal imaging, genetic and behavioral findings in humans and mice revealed that metabotropic glutamate receptors of subtype 5 contribute to the molecular machinery keeping track of sleep need and coping with physiological and behavioral consequences of sleep loss, pointing to novel targets for improved wakefulness and sleep.

Controlling for the effects of mechanical stimulation during sleep deprivation reveals substantial multi-cycle sleep rebound in Drosophila and reveals serotonin as a potential sleep substance in the fly brain.

Shank3, a high confidence autism gene candidate, may be a key component of the mechanisms underlying sleep problems in autism.

Sleep deprivation enhances energy-dense food choices and encoding of olfactory information in the human brain.

The circadian clock gates sleep drive by modulating sleep homeostat neurons.

The sleep-deprived brain in humans undergoes upscaled intracortical excitability which diminishes induction of LTP-like plasticity via transcranial electrical stimulation while converting the LTD-like to LTP-like plasticity and these physiological changes couple with impaired learning, memory, and attention at behavioral level.

Sleep-wake patterns, together with a suprachiasmatic nuclei-independent circadian factor, are necessary and sufficient to maintain high-amplitude nychthemeral rhythms in PERIOD-2.