5,323 results found
    1. Neuroscience

    Slo2 potassium channel function depends on RNA editing-regulated expression of a SCYL1 protein

    Long-Gang Niu, Ping Liu ... Bojun Chen
    The pseudokinase protein SCYL1 is an evolutionarily conserved enhancer of Slo2 potassium channel activity.
    1. Developmental Biology
    2. Neuroscience

    Slow oscillation-spindle coupling predicts enhanced memory formation from childhood to adolescence

    Michael A Hahn, Dominik Heib ... Randolph F Helfrich
    An individualized cross-frequency coupling approach identified slow oscillation-spindle coupling strength as a novel mechanism that mediates memory formation during cortical maturation.
    1. Neuroscience

    Sigma oscillations protect or reinstate motor memory depending on their temporal coordination with slow waves

    Judith Nicolas, Bradley R King ... Genevieve Albouy
    Sigma oscillations have a dual role in motor memory consolidation depending on their temporal coordination with slow waves during post-learning sleep.
    1. Neuroscience

    Timely coupling of sleep spindles and slow waves linked to early amyloid-β burden and predicts memory decline

    Daphne Chylinski, Maxime Van Egroo ... Gilles Vandewalle
    Altered coupling of different brain waves during sleep is associated with worse brain features related to Alzheimer’s disease processes and cognitive performance, suggesting that sleep brain waves coupling may contribute to poorer brain and cognitive trajectories in ageing.
    1. Neuroscience

    Sleep spindle maturity promotes slow oscillation-spindle coupling across child and adolescent development

    Ann-Kathrin Joechner, Michael A Hahn ... Markus Werkle-Bergner
    Across four samples of children, adolescents, and young adults, age-related higher similarity of dominant, development-specific fast sleep spindles and adult-like fast sleep spindles is uniquely related to stronger and more precise slow oscillation-sleep spindle coupling.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    The Ca2+-activated K+ current of human sperm is mediated by Slo3

    Christoph Brenker, Yu Zhou ... Timo Strünker
    The principal potassium ion channel in human sperm, Slo3, is primarily activated by calcium ions and controls the membrane potential of human sperm by intracellular calcium ion levels rather than intracellular pH.
    1. Neuroscience

    Closed-loop auditory stimulation method to modulate sleep slow waves and motor learning performance in rats

    Carlos G Moreira, Christian R Baumann ... Daniela Noain
    Delivery of auditory triggers as unique slow waves-targeting approach yields efficient, stable, and precise modulation of slow-wave activity in rats.
    1. Neuroscience

    Somatostatin interneurons activated by 5-HT2A receptor suppress slow oscillations in medial entorhinal cortex

    Roberto de Filippo, Benjamin R Rost ... Dietmar Schmitz
    Somatostatin interneurons are novel mediators of serotonergic modulation in entorhinal cortex via activation of 5-HT2A receptors, a receptor involved in the etiology of different psychiatric disorders.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Slo1 is the principal potassium channel of human spermatozoa

    Nadja Mannowetz, Natasha M Naidoo ... Polina V Lishko
    Potassium ions enter and leave human sperm cells via a calcium-dependent ion channel that is also pH-independent.
    1. Structural Biology and Molecular Biophysics

    Molecular structures of the human Slo1 K+ channel in complex with β4

    Xiao Tao, Roderick MacKinnon
    The structures of Slo1 in complex with b4 imply that the auxiliary beta subunits modulate the channel's gating properties through stabilizing ‘pre-existing’ conformations rather than creating new ones.

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