1,096 results found
    1. Neuroscience

    Two forms of asynchronous release with distinctive spatiotemporal dynamics in central synapses

    Gerardo Malagon, Jongyun Myeong, Vitaly A Klyachko
    Asynchronous release is not uniform, but comprises two subpopulations of events, one occurring inside the active zone and another occurring ectopically, which are characterized by distinctive spatiotemporal dynamics in hippocampal synapses.
    1. Cell Biology
    2. Structural Biology and Molecular Biophysics

    Spatiotemporal dynamics of PIEZO1 localization controls keratinocyte migration during wound healing

    Jesse R Holt, Wei-Zheng Zeng ... Medha M Pathak
    Piezo1 activity within keratinocytes slows healing of wounded skin via dynamic channel enrichment at regions of the wound edge, causing localized retraction and thus hindering keratinocyte migration during wound healing.
    1. Computational and Systems Biology
    2. Physics of Living Systems

    Optogenetics enables real-time spatiotemporal control over spiral wave dynamics in an excitable cardiac system

    Rupamanjari Majumder, Iolanda Feola ... Daniel A Pijnappels
    Free optical steering of spiral waves by attraction-based dragging of their cores in optogenetically modified cardiac tissue.
    1. Neuroscience

    Spatiotemporal dynamics of multi-vesicular release is determined by heterogeneity of release sites within central synapses

    Dario Maschi, Vitaly A Klyachko
    Release site heterogeneity represents a previously unknown level of structural and functional organization within individual active zones in central synapses, which determines the spatiotemporal dynamics of multi-vesicular release.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Signaling diversity enabled by Rap1-regulated plasma membrane ERK with distinct temporal dynamics

    Jeremiah Keyes, Ambhighainath Ganesan ... Jin Zhang
    An individual extracellular signal regulates multiple cellular actions through differences in the temporal dynamics of spatially distinct populations of the central signaling enzyme, extracellular-signal regulated kinase.
    1. Neuroscience

    Spatiotemporal neural dynamics of object recognition under uncertainty in humans

    Yuan-hao Wu, Ella Podvalny, Biyu J He
    Combining 7 Tesla fMRI and MEG data collected during a challenging visual recognition task revealed distinct neural representational formats in ventral visual and frontoparietal regions, and the emergence of recognition-related signals prior to category-related information.
    1. Developmental Biology

    Spatiotemporal dynamics and heterogeneity of renal lymphatics in mammalian development and cystic kidney disease

    Daniyal J Jafree, Dale Moulding ... David A Long
    Three-dimensional imaging was used to identify structural and quantitative features of developing lymphatics in the kidneys of mice, humans and in a genetic mouse model of polycystic kidney disease.
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    1. Neuroscience

    Transformation of spatiotemporal dynamics in the macaque vestibular system from otolith afferents to cortex

    Jean Laurens, Sheng Liu ... Dora E Angelaki
    The spatial and dynamic properties of self-motion signals are acquired at the first stage of otolith signal transformation, which is in the brainstem and cerebellum, and conserved across brainstem, cerebellar and cortical areas.
    1. Neuroscience

    Eye movements reveal spatiotemporal dynamics of visually-informed planning in navigation

    Seren Zhu, Kaushik J Lakshminarasimhan ... Dora E Angelaki
    The spatial and temporal patterns of eye movements exhibited by humans in virtual reality reveal how they plan paths when navigating in complex, naturalistic environments.
    1. Computational and Systems Biology

    DIPPER, a spatiotemporal proteomics atlas of human intervertebral discs for exploring ageing and degeneration dynamics

    Vivian Tam, Peikai Chen ... Danny Chan
    Deep and comprehensive proteomic resource of human intervertebral disc at high spatial resolution with a methodological flow reveals new insights in disc homeostasis and degeneration.

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