273 results found
    1. Biochemistry and Chemical Biology
    2. Chromosomes and Gene Expression

    Free spermidine evokes superoxide radicals that manifest toxicity

    Vineet Kumar, Rajesh Kumar Mishra ... Dipak Dutta
    Spermidine-mediated superoxide generation affects iron homeostasis in Escherichia coli.
    1. Immunology and Inflammation

    Autophagy in T cells from aged donors is maintained by spermidine and correlates with function and vaccine responses

    Ghada Alsaleh, Isabel Panse ... Anna Katharina Simon
    Declining TFEB and autophagy levels with age are key to poor vaccination efficacy in the elderly.
    1. Microbiology and Infectious Disease

    Host-induced spermidine production in motile Pseudomonas aeruginosa triggers phagocytic uptake

    Sebastian Felgner, Matthias Preusse ... Susanne Häussler
    Upon host cell contact, motile but not non-motile Pseudomonas aeruginosa exhibit a change in their gene expression program that includes the expression of spermidine, which triggers motility-dependent phagocytosis.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    A back-door insight into the modulation of Src kinase activity by the polyamine spermidine

    Sofia Rossini, Marco Gargaro ... Giada Mondanelli
    A road to modulators of the kinase activity and the non-enzymatic functions of Src and IDO1 at once.
    1. Microbiology and Infectious Disease

    Inverse regulation of Vibrio cholerae biofilm dispersal by polyamine signals

    Andrew A Bridges, Bonnie L Bassler
    The global pathogen Vibrio cholerae monitors environmental polyamines to garner information about numbers of ‘self’ versus ‘other’ in the vicinity, and in response, to remain or disperse from biofilms.
    1. Immunology and Inflammation

    Autophagy is a critical regulator of memory CD8+ T cell formation

    Daniel J Puleston, Hanlin Zhang ... Anna Katharina Simon
    Autophagy is required for CD8+ T cell memory formation; in aged individuals autophagy levels are diminished, and increasing autophagy enhances their CD8+ T cell responses.
    1. Structural Biology and Molecular Biophysics

    Screening of candidate substrates and coupling ions of transporters by thermostability shift assays

    Homa Majd, Martin S King ... Edmund RS Kunji
    It is technically difficult to identify transport proteins, but here a method is presented that exploits the principle that they are stabilized in detergent solution when they bind their substrate.
    1. Neuroscience

    Enhanced functional detection of synaptic calcium-permeable AMPA receptors using intracellular NASPM

    Ian Coombs, Cécile Bats ... Mark Farrant
    Intracellular NASPM, unlike the widely used spermine, fully blocks outward currents through calcium-permeable AMPA-type glutamate receptors, enabling an improved functional readout for this physiologically important receptor subtype in neurons.
    1. Structural Biology and Molecular Biophysics

    ATP and large signaling metabolites flux through caspase-activated Pannexin 1 channels

    Adishesh K Narahari, Alex JB Kreutzberger ... Douglas A Bayliss
    Purified Pannexin 1 channels activated by caspase cleavage in proteoliposomes reconstitute a permeation pathway for intercellular signaling molecules important in inflammation and cell clearance.
    1. Chromosomes and Gene Expression
    2. Physics of Living Systems

    Regulation of chromatin microphase separation by binding of protein complexes

    Omar Adame-Arana, Gaurav Bajpai ... Samuel Safran
    Chromatin-binding proteins regulate the effective solvent quality experienced by chromatin and impact global chromatin organization in the nucleus.

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