A novel quantitative framework to analyse the inner structure of tumour spheroids in terms of the mechanisms that underly growth.

The forces that multicellular tumor aggregates exert on their environment lead to non-linear, scale-invariant tissue deformations far away from the tumor, which can be exploited to quantify its collective contractility.

Combined EGFR and SOS1 inhibition synergize to inhibit NSCLC spheroid growth.

A novel mechanoelectrical transduction pathway can regulate the interactions of melanoma cells and their surrounding microenvironment, impacting both migration and cell dissociation from organotypic spheroids.

Directed differentiation of stem cells can generate ventral-anterior foregut spheroids that can expand into three-dimensional lung organoids with striking structural, cellular and molecular similarities to the human fetal lung.

A systemic hormone controls progenitor fate decisions independent of local fate determining pathways in the adult intestinal stem cell niche of Drosophila melanogaster..

Coordinated microRNAs activity induced by VEGF represses cell proliferation and favors cell migration at the onset of sprouting angiogenesis in endothelial cells.

Theoretical predictions and experiments on multicellular aggregates indicate that the extracellular matrix acts as a mechanical sensor, which regulates cell proliferation and migration in a three-dimensional environment.