195 results found
    1. Cell Biology

    A FRET-based study reveals site-specific regulation of spindle position checkpoint proteins at yeast centrosomes

    Yuliya Gryaznova, Ayse Koca Caydasi ... Gislene Pereira
    Daughter-cell-associated factors and centrosome-based regulation is important in mitotic exit and spindle position checkpoint control.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A molecular basis for the differential roles of Bub1 and BubR1 in the spindle assembly checkpoint

    Katharina Overlack, Ivana Primorac ... Andrea Musacchio
    The mechanism behind the recruitment of the spindle assembly checkpoint protein BubR1 to the kinetochore illustrates how gene duplication and sub-functionalization can influence the functional complexity of a protein network.
    1. Cell Biology

    The copy-number and varied strengths of MELT motifs in Spc105 balance the strength and responsiveness of the spindle assembly checkpoint

    Babhrubahan Roy, Simon JY Han ... Ajit P Joglekar
    Cell biological and genetic analyses reveal how budding yeast cells optimize Spindle Assembly checkpoint signaling to maximize chromosome segregation accuracy and minimize unnecessary delays in anaphase onset.
    1. Structural Biology and Molecular Biophysics
    2. Cell Biology

    Bub3 reads phosphorylated MELT repeats to promote spindle assembly checkpoint signaling

    Ivana Primorac, John R Weir ... Andrea Musacchio
    The spindle assembly protein Bub3 recruits the checkpoint kinase Bub1 to kinetochores by binding to phosphorylated MELT repeats in the kinetochore subunit Knl1.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    TRIP13 is a protein-remodeling AAA+ ATPase that catalyzes MAD2 conformation switching

    Qiaozhen Ye, Scott C Rosenberg ... Kevin D Corbett
    TRIP13 inactivates the spindle assembly checkpoint by converting MAD2 from its active ‘closed’ state to its inactive ‘open’ state.
    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Deletion of the MAD2L1 spindle assembly checkpoint gene is tolerated in mouse models of acute T-cell lymphoma and hepatocellular carcinoma

    Floris Foijer, Lee A Albacker ... Peter K Sorger
    Chromosomal instability through spindle assembly checkpoint alleviation facilitates malignant transformation of hepatocytes and T-cells in vivo, resulting in cancers with recurrent karyotypes.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    A sequential multi-target Mps1 phosphorylation cascade promotes spindle checkpoint signaling

    Zhejian Ji, Haishan Gao ... Hongtao Yu
    The spindle checkpoint kinase Mps1 sequentially phosphorylates multiple substrates to amplify checkpoint signals, making the checkpoint highly dependent on Mps1 function and directly responsive to kinetochore-microtubule attachment.
    1. Cell Biology

    The equatorial position of the metaphase plate ensures symmetric cell divisions

    Chia Huei Tan, Ivana Gasic ... Patrick Meraldi
    Human cells center the position of the metaphase plate before anaphase onset to ensure the formation of equal-sized daughter cells.
    1. Cell Biology

    Protein Phosphatase 1 inactivates Mps1 to ensure efficient Spindle Assembly Checkpoint silencing

    Margarida Moura, Mariana Osswald ... Carlos Conde
    Inactivation of the master mitotic checkpoint regulator Mps1 by protein phosphatase 1 is required for timely segregation of the genetic material during cell division.
    1. Cell Biology

    Protein phosphatase 1 in association with Bud14 inhibits mitotic exit in Saccharomyces cerevisiae

    Dilara Kocakaplan, Hüseyin Karabürk ... Ayse Koca Caydasi
    PP1-Bud14 is a novel Spindle Position Checkpoint component.

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