23 results found
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    EBI2-mediated bridging channel positioning supports splenic dendritic cell homeostasis and particulate antigen capture

    Tangsheng Yi, Jason G Cyster
    The receptor EBI2 is essential for correctly positioning CD4+ dendritic cells in the spleen so that they can present blood-borne antigens to T cells and thereby provoke an antibody response.
    1. Genetics and Genomics

    Obesity-linked suppression of membrane-bound O-acyltransferase 7 (MBOAT7) drives non-alcoholic fatty liver disease

    Robert N Helsley, Venkateshwari Varadharajan ... J Mark Brown
    Loss of function of membrane-bound O-acyltransferase 7 (MBOAT7), but not transmembrane channel-like 4 (TMC4), promotes hepatic steatosis.
    1. Immunology and Inflammation
    2. Microbiology and Infectious Disease

    An extrafollicular pathway for the generation of effector CD8+ T cells driven by the proinflammatory cytokine, IL-12

    Suhagi Shah, Gijsbert M Grotenbreg ... George S Yap
    Proliferation and differentiation of CD8+ T cells into terminal effectors occurs in the marginal zone and red pulp, and is promoted by IL-12 through direct and indirect mechanisms.
    1. Immunology and Inflammation

    The anti-caspase 1 inhibitor VX-765 reduces immune activation, CD4+ T cell depletion, viral load, and total HIV-1 DNA in HIV-1 infected humanized mice

    Mathieu Amand, Philipp Adams ... Carole Seguin-Devaux
    Inflamasomme inhibition prevents immune activation, HIV-1 pathogenesis and the splenic content of HIV-1 total DNA in humanized mice when administrated early after HIV-1 infection.
    1. Neuroscience

    Analysis of the immune response to sciatic nerve injury identifies efferocytosis as a key mechanism of nerve debridement

    Ashley L Kalinski, Choya Yoon ... Roman J Giger
    In the injured sciatic nerve, blood-derived monocytes and macrophages eat dying leukocytes, thereby contributing to nerve debridement and inflammation resolution, and this correlates with neuronal regeneration.
    1. Cell Biology
    2. Developmental Biology

    Distinct and diverse chromatin proteomes of ageing mouse organs reveal protein signatures that correlate with physiological functions

    Giorgio Oliviero, Sergey Kovalchuk ... Ole N Jensen
    Quantitative proteomics reveals the diversity and heterogeneity of nuclear proteomes in mammalian organs and identifies the molecular features of ageing.
    1. Neuroscience

    Oxytocin-mediated social enrichment promotes longer telomeres and novelty seeking

    Jamshid Faraji, Mitra Karimi ... Gerlinde AS Metz
    Social enrichment supports longevity.
    1. Computational and Systems Biology

    Population dynamics of immunological synapse formation induced by bispecific T cell engagers predict clinical pharmacodynamics and treatment resistance

    Can Liu, Jiawei Zhou ... Yanguang Cao
    Modeling the dynamics of immunological synapses informs pharmacodynamics and treatment resistance to bispecific T cell engagers.
    1. Cancer Biology
    2. Stem Cells and Regenerative Medicine

    Reprogramming and redifferentiation of mucosal-associated invariant T cells reveal tumor inhibitory activity

    Chie Sugimoto, Yukie Murakami ... Hiroshi Wakao
    Mucosal-associated invariant T cells, an emerging member of the innate-like T cells abundant in humans bridging the innate and the adaptive immunity, could be exploited as a novel tool for cancer immunotherapy through cell reprogramming.
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Transformer-based spatial–temporal detection of apoptotic cell death in live-cell imaging

    Alain Pulfer, Diego Ulisse Pizzagalli ... Santiago Fernandez Gonzalez
    ADeS, a novel deep learning approach for apoptosis detection, achieves 98% accuracy in vitro and in vivo while providing unprecedented insights into the spatial–temporal foundation of cell death.

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