The receptor EBI2 is essential for correctly positioning CD4+ dendritic cells in the spleen so that they can present blood-borne antigens to T cells and thereby provoke an antibody response.
Suhagi Shah, Gijsbert M Grotenbreg ... George S Yap
Proliferation and differentiation of CD8+ T cells into terminal effectors occurs in the marginal zone and red pulp, and is promoted by IL-12 through direct and indirect mechanisms.
Mathieu Amand, Philipp Adams ... Carole Seguin-Devaux
Inflamasomme inhibition prevents immune activation, HIV-1 pathogenesis and the splenic content of HIV-1 total DNA in humanized mice when administrated early after HIV-1 infection.
In the injured sciatic nerve, blood-derived monocytes and macrophages eat dying leukocytes, thereby contributing to nerve debridement and inflammation resolution, and this correlates with neuronal regeneration.
Giorgio Oliviero, Sergey Kovalchuk ... Ole N Jensen
Quantitative proteomics reveals the diversity and heterogeneity of nuclear proteomes in mammalian organs and identifies the molecular features of ageing.
Mucosal-associated invariant T cells, an emerging member of the innate-like T cells abundant in humans bridging the innate and the adaptive immunity, could be exploited as a novel tool for cancer immunotherapy through cell reprogramming.
Alain Pulfer, Diego Ulisse Pizzagalli ... Santiago Fernandez Gonzalez
ADeS, a novel deep learning approach for apoptosis detection, achieves 98% accuracy in vitro and in vivo while providing unprecedented insights into the spatial–temporal foundation of cell death.