3,989 results found
    1. Stem Cells and Regenerative Medicine

    Derivation of trophoblast stem cells from naïve human pluripotent stem cells

    Chen Dong, Mariana Beltcheva ... Thorold W Theunissen
    Naive hPSCs can readily give rise to human trophoblast stem cells, thus demonstrating their extraembryonic lineage potential and providing a new model system to study human trophectoderm specification.
    1. Cell Biology
    2. Stem Cells and Regenerative Medicine

    Human perivascular stem cell-derived extracellular vesicles mediate bone repair

    Jiajia Xu, Yiyun Wang ... Aaron Watkins James
    Perivascular extracellular vesicles induce bone repair, and do so via tetraspanin binding to recipient skeletal progenitor cells.
    1. Stem Cells and Regenerative Medicine

    External signals regulate continuous transcriptional states in hematopoietic stem cells

    Eva M Fast, Audrey Sporrij ... Leonard I Zon
    In vivo modulation of the prostaglandin, interferon, or granulocyte colony-stimulating factor pathway induces rapid and specific transcriptional changes in hematopoietic stem cells with significant heterogeneity in the cellular response.
    1. Stem Cells and Regenerative Medicine

    The neural crest is a source of mesenchymal stem cells with specialized hematopoietic stem cell niche function

    Joan Isern, Andrés García-García ... Simón Méndez-Ferrer
    Developing long bones contain distinct mesenchymal stem-cell populations derived from mesoderm and neural crest, which have specialized functions in skeleton formation and the establishment of the hematopoietic stem-cell niche, respectively.
    1. Genetics and Genomics
    2. Stem Cells and Regenerative Medicine

    Highly efficient generation of isogenic pluripotent stem cell models using prime editing

    Hanqin Li, Oriol Busquets ... Frank Soldner
    A highly efficient platform to engineer designer mutations in human stem cells using RNA-based delivery of prime editing components.
    1. Stem Cells and Regenerative Medicine

    Stem cells repurpose proliferation to contain a breach in their niche barrier

    Kenneth Lay, Shaopeng Yuan ... Elaine Fuchs
    Adult stem cells sense nearby tissue damage and recruit immune cells to help them direct efforts towards containing a breach in the epithelial barrier.
    1. Neuroscience
    2. Stem Cells and Regenerative Medicine

    Activation of a neural stem cell transcriptional program in parenchymal astrocytes

    Jens P Magnusson, Margherita Zamboni ... Jonas Frisén
    Parenchymal astrocytes are quiescent neural stem cells whose neurogenic potential can be unleashed by targeted manipulations guided by single-cell RNA sequencing data.
    1. Developmental Biology
    2. Neuroscience

    Wnt signaling mediates acquisition of blood–brain barrier properties in naïve endothelium derived from human pluripotent stem cells

    Benjamin D Gastfriend, Hideaki Nishihara ... Eric V Shusta
    Activation of Wnt/β-catenin signaling in endothelial progenitors derived from human pluripotent stem cells partially induces the specialized blood–brain barrier phenotype while the same treatment in matured endothelial cells is less efficacious.
    1. Stem Cells and Regenerative Medicine

    Physiological and stem cell compartmentalization within the Drosophila midgut

    Alexis Marianes, Allan C Spradling
    The intestine contains distinct subregions specialized for digestion along its anterior-posterior axis, and the stem cells that constantly renew these subregions are not interchangeable.
    1. Stem Cells and Regenerative Medicine

    Conserved functional antagonism of CELF and MBNL proteins controls stem cell-specific alternative splicing in planarians

    Jordi Solana, Manuel Irimia ... Nikolaus Rajewsky
    A conserved alternative splicing program is specific to planarian stem cells and is controlled by the highly conserved splicing factors CELF and MBNL; therefore, this mode of regulating stem cells is likely ancestral to all animals.

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