314 results found
    1. Cell Biology

    Defective STIM-mediated store operated Ca2+ entry in hepatocytes leads to metabolic dysfunction in obesity

    Ana Paula Arruda, Benedicte Mengel Pers ... Gökhan S Hotamisligil
    Store operated calcium entry is defective in hepatocytes of obese mice, and restoring this process is sufficient to improve glucose metabolism.
    1. Structural Biology and Molecular Biophysics

    STIM1-dependent peripheral coupling governs the contractility of vascular smooth muscle cells

    Vivek Krishnan, Sher Ali ... Scott Earley
    STIM1 regulates the contractility of blood vessels and blood pressure by organizing membrane contact sites and ion channel activity in vascular smooth muscle cells in a manner that is independent of its canonical function in store-operated Ca2+entry.
    1. Structural Biology and Molecular Biophysics
    2. Biochemistry and Chemical Biology

    A pathogenic human Orai1 mutation unmasks STIM1-independent rapid inactivation of Orai1 channels

    Priscilla S-W Yeung, Megumi Yamashita, Murali Prakriya
    A human Orai1 mutation linked to tubular myopathy activates Orai1 channels independently of STIM1 and unmasks calcium-dependent inactivation of Orai1 channels.
    1. Cell Biology

    An essential and NSF independent role for α-SNAP in store-operated calcium entry

    Yong Miao, Cathrine Miner ... Monika Vig
    α-SNAP mediated rearrangement of Stim1 and Orai1 molecules within CRAC channel clusters is required for store-operated calcium entry.
    1. Cell Biology
    2. Neuroscience

    Regulation of store-operated Ca2+ entry by IP3 receptors independent of their ability to release Ca2+

    Pragnya Chakraborty, Bipan Kumar Deb ... Gaiti Hasan
    Binding of the second messenger inositol 1,4,5-trisphosphate to its intracellular receptor drives interaction between the intracellular Ca2+ sensor STIM and the plasma membrane localized Ca2+ channel Orai and raises the level of store-operated Ca2+ entry in mammalian cells.
    1. Structural Biology and Molecular Biophysics

    Conformational dynamics of auto-inhibition in the ER calcium sensor STIM1

    Stijn van Dorp, Ruoyi Qiu ... Richard S Lewis
    Single-molecule FRET measurements and protein crosslinking reveal the compact structure of quiescent STIM1 and the conformational rearrangements that enable it to activate store-operated calcium entry.
    1. Structural Biology and Molecular Biophysics

    Arteries: STIMulating blood pressure

    Tessa AC Garrud, Jonathan H Jaggar
    The protein STIM1 helps to maintain membrane coupling sites in smooth muscle cells that regulate arterial contractility and blood pressure.
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    1. Biochemistry and Chemical Biology

    A secretory pathway kinase regulates sarcoplasmic reticulum Ca2+ homeostasis and protects against heart failure

    Adam J Pollak, Canzhao Liu ... Jack E Dixon
    Protein phosphorylation within the lumen of the secretory pathway regulates cardiac function.
    1. Immunology and Inflammation

    Na+ influx via Orai1 inhibits intracellular ATP-induced mTORC2 signaling to disrupt CD4 T cell gene expression and differentiation

    Yong Miao, Jaya Bhushan ... Monika Vig
    Non-specific sodium entry inhibits T cell receptor induced gene expression and differentiation of T cells by depleting intracellular ATP and disrupting mTORC2 dependent signalling axis.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    Near-infrared photoactivatable control of Ca2+ signaling and optogenetic immunomodulation

    Lian He, Yuanwei Zhang ... Yubin Zhou
    A near-infrared light-stimulable optogenetic platform enables remote and wireless manipulation of calcium signaling and immune responses both in vitro and in vivo to achieve tailored function.

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