3,007 results found
    1. Microbiology and Infectious Disease
    2. Plant Biology

    Point of View: The challenges faced by living stock collections in the USA

    Kevin McCluskey, Kyria Boundy-Mills ... Erich Grotewold
    Living stock collections provide invaluable resources to research communities, yet they face significant challenges.
    1. Developmental Biology

    Spatiotemporally controlled genetic perturbation for efficient large-scale studies of cell non-autonomous effects

    Andrea Chai, Ana M Mateus ... Rita Sousa-Nunes
    A novel genetic strategy for induction of reproducible neural tumors (or any other deleterious phenotype) in a single Drosophila stock (applicable to other organisms).
    1. Developmental Biology

    In vivo study of gene expression with an enhanced dual-color fluorescent transcriptional timer

    Li He, Richard Binari ... Norbert Perrimon
    A simple and effective method facilitates the study of in vivo transcriptional dynamics using transcriptional enhancers and destabilized fluorescent protein, which is suitable for both live imaging and fixed studies.
    1. Cancer Biology

    Persistent effects of pair bonding in lung cancer cell growth in monogamous Peromyscus californicus

    Asieh Naderi, Elham Soltanmaohammadi ... Hippokratis Kiaris
    Monogamous rodents of the genus Peromyscus, upon disruption of pair bonds, acquire increased oncogenic activity.
    1. Developmental Biology
    2. Evolutionary Biology

    An epithelial signalling centre in sharks supports homology of tooth morphogenesis in vertebrates

    Alexandre P Thiery, Ariane SI Standing ... Gareth J Fraser
    The development of diverse tooth shapes among vertebrates, from sharks to mammals, is a highly conserved process, utilising a similar dental signalling centre for more than 400 million years.
    1. Developmental Biology
    2. Neuroscience

    Maturation of a central brain flight circuit in Drosophila requires Fz2/Ca2+ signaling

    Tarjani Agrawal, Gaiti Hasan
    Gene knockdown experiments in fruit fly pupae reveal the role of the signaling molecule 'dFrizzled2' in the development of a neural circuit that helps insects to fly continuously for extended periods.
    1. Genetics and Genomics

    Auxin exposure disrupts feeding behavior and fatty acid metabolism in adult Drosophila

    Sophie A Fleck, Puja Biswas ... Lesley N Weaver
    Adult Drosophila exposed to auxin at the recommended concentrations for the AGES transgene expression system display defects in feeding behavior, have altered metabolic transcripts, and have reduced triacylglyceride levels.
    1. Genetics and Genomics

    An efficient CRISPR-based strategy to insert small and large fragments of DNA using short homology arms

    Oguz Kanca, Jonathan Zirin ... Hugo J Bellen
    Optimization of homology donor DNA production and integration schemes facilitates homologous recombination in vivo and in cell culture in Drosophila melanogaster..
    1. Genetics and Genomics

    A confinable home-and-rescue gene drive for population modification

    Nikolay P Kandul, Junru Liu ... Omar S Akbari
    Generation of a home-and-rescue gene drive targeting an essential gene reveals confinable population modification.
    1. Cell Biology
    2. Developmental Biology

    The fat body cortical actin network regulates Drosophila inter-organ nutrient trafficking, signaling, and adipose cell size

    Rupali Ugrankar-Banerjee, Son Tran ... W Mike Henne
    Fat-body-specific loss of actin isoform Act5C disrupts fat body cell growth and fat storage, lipoprotein secretion, and insulin signaling, revealing a non-canonical role for the cortical actin cytoskeleton in nutrient signaling and inter-organelle trafficking.

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