1,267 results found
    1. Neuroscience

    Neuromodulation of striatal D1 cells shapes BOLD fluctuations in anatomically connected thalamic and cortical regions

    Marija Markicevic, Oliver Sturman ... Nicole Wenderoth
    The structural characteristics of a circuit and its hierarchical dimensions are shown to influence regional time-series dynamics after targeted cellular-level manipulations.
    1. Neuroscience

    Medium spiny neurons activity reveals the discrete segregation of mouse dorsal striatum

    Javier Alegre-Cortés, María Sáez ... Ramon Reig
    Analysis of slow wave brain state unravels the functional connectivity and the biological substrate of the rodent dorsolateral and dorsomedial striatum, demonstrating its organization in two non-overlapping circuits.
    1. Developmental Biology
    2. Neuroscience

    Unbiased identification of novel transcription factors in striatal compartmentation and striosome maturation

    Maria-Daniela Cirnaru, Sicheng Song ... Michelle E Ehrlich
    RNAseq and ATACseq are utilized to identify transcription factors participating in striatal compartmentation into striosome and matrix, and roles for Stat1, Olig2, and Foxf2 are validated in vitro and in vivo.
    1. Neuroscience

    Egr2 induction in spiny projection neurons of the ventrolateral striatum contributes to cocaine place preference in mice

    Diptendu Mukherjee, Ben Jerry Gonzales ... Ami Citri
    The ventrolateral striatum is found to be recruited during the encoding of cocaine preference, within which Egr2-expressing ensembles are functionally important, as is the expression of Egr2 within them.
    1. Neuroscience

    A striatal circuit balances learned fear in the presence and absence of sensory cues

    Michael Kintscher, Olexiy Kochubey, Ralf Schneggenburger
    Direct- and indirect pathway neurons of the posterior striatum display divergent in vivo and ex vivo plasticity after fear learning, and differentially modulate defensive behaviors displayed in the presence, and absence of threat-predicting sensory cues.
    1. Neuroscience

    Distinct recruitment of dorsomedial and dorsolateral striatum erodes with extended training

    Youna Vandaele, Nagaraj R Mahajan ... Patricia H Janak
    Dorsomedial and dorsolateral striatal neural activity differ during early learning of action sequences but do not change with performance improvement across sessions, and become similar after extended training.
    1. Neuroscience

    Striatal direct and indirect pathway neurons differentially control the encoding and updating of goal-directed learning

    James Peak, Billy Chieng ... Bernard W Balleine
    Direct and indirect pathway neurons in posterior dorsomedial striatum were found to play distinct roles, with the former necessary for encoding and the latter for updating goal-directed learning.
    1. Neuroscience

    Distinct temporal difference error signals in dopamine axons in three regions of the striatum in a decision-making task

    Iku Tsutsui-Kimura, Hideyuki Matsumoto ... Mitsuko Watabe-Uchida
    Dopamine signals in the ventral, dorsomedial, and dorsolateral striatum are modulated by various variables, such as stimulus-associated value, choice, confidence, but these modulations can be inclusively explained by TD errors.
    1. Neuroscience

    Coordination of rapid cholinergic and dopaminergic signaling in striatum during spontaneous movement

    Mark Howe, Imane Ridouh ... Daniel A Dombeck
    Optical recordings reveal previously unknown neuromodulator dynamics in the striatum during animal movements that suggest a new interpretation of the underpinnings of bradykinetic movements exhibited in Parkinson's Disease patients.
    1. Neuroscience

    Striatal action-value neurons reconsidered

    Lotem Elber-Dorozko, Yonatan Loewenstein
    The numerous reports in support of action-value representation in the striatum are based on statistical analyses that are subject to two critical confounds and, thus, this long-held belief of striatal action-value representation should be retested using different experiments and analyses.

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