The ubiquitous second messenger cyclic AMP, produced by Rv3645/MacE, controls long-chain fatty acid metabolism and intrinsic multidrug resistance in M. tuberculosis.

A suppressor screen of dominant-negative synaptotagmin-induced lethality in Drosophila identifies key properties of the protein that regulate fusion, including the SNARE interaction surface.

Zebrafish embryo screen utilizing conserved mechanisms between cancer metastasis and zebrafish gastrulation identifies the HTR2C inhibitor pizotifen as anti-metastasis drugs.

In the fungal pathogen Cryptococcus neoformans, the RAM pathway, potentially through post-transcriptional regulation, plays an essential role in adaptation to host temperature and CO₂.

The protein p53 negatively impacts the ability of a CRISPR screen to discriminate between essential and non-essential genes, hence, p53 status should be considered in these screens.

Experimental determination of residue contacts from mutational data allows model discrimination and identification of in vivo functional conformations of proteins.

Genetic suppressor screens with C. elegans reveal a novel function for the Death Associated Protein Kinase in regulation of epithelial microtubule dynamics.

The anticonvulsant drug lamotrigine inhibits bacterial ribosome biogenesis and reveals an unexplored role for initiation factor 2 (IF2) in ribosome assembly.

A systematic genetic analysis comprising seven genome-wide screens in haploid human cells uncovered new regulatory mechanisms at most levels in the WNT signaling pathway.

In contrast with earlier conclusions, negative selection has a major role in cancer evolution.