A new method allows silver- and gold-labeled tissues to be imaged with confocal microscopy, avoiding the problem of fluorescence photobleaching.

Intravascular triglyceride hydrolysis by lipoprotein lipase is crucial for delivering lipid nutrients to vital tissues, such as the heart, skeletal muscle, and adipose tissue.

Term-seq, genetic and biochemical experiments reveal that the trans-action factor aCPSF1 and the terminator U-tract cis-element work in a noteworthy two-in-one termination mode in archaea, and may represent an archetypal mode of the eukaryotic RNA polymerase II termination machinery.

The non-signaling complex formed by Activin A and ACVR1 is operant in vivo and is required to temper the degree of heterotopic ossification in the genetic disorder fibrodysplasia ossificans progressiva.

The rational drug design combining the bioassay identified a novel selective androgen receptor (AR) degrader for both AR and AR-VRs and illustrated the synergistic importance of AR antagonism and degradation in advanced prostate cancer treatment.

The safety and strong antitumor effects of GPC1-specific CAR-T cells against GPC1-expressing solid tumors were demonstrated by using both syngeneic and xenogeneic mouse models.

Common variants of the SARS-CoV-2 Spike protein and its ligand, the human ACE2 receptor, increase the binding affinity, suggesting that they could increase viral transmissibility.

A structure-function analysis of the YAP:TEAD interaction permits a thermodynamic mapping of this interface.

A network, composed of 22 relatives of the Beaten Path and Sidestep immunoglobulin superfamily cell surface proteins, also includes several neuronal Beaten Path subfamily receptors which interact selectively with Sidestep subfamily proteins expressed on peripheral tissues.

The crystal structure of a PfRh family protein from a malaria parasite has been solved and shows that PfRh5-which the parasite uses to invade human red blood cells-has a novel protein fold.