1,830 results found
    1. Neuroscience

    Nanoconnectomic upper bound on the variability of synaptic plasticity

    Thomas M Bartol Jr, Cailey Bromer ... Terrence J Sejnowski
    Spine heads on the same dendrite receiving input from the same axon are the same size.
    1. Genetics and Genomics
    2. Neuroscience

    Mayday sustains trans-synaptic BMP signaling required for synaptic maintenance with age

    Jessica M Sidisky, Daniel Weaver ... Daniel Babcock
    Maintaining synaptic structure and function over time requires continuous signaling from pathways that are crucial for synapse development.
    1. Immunology and Inflammation

    Composition and structure of synaptic ectosomes exporting antigen receptor linked to functional CD40 ligand from helper T cells

    David G Saliba, Pablo F Céspedes-Donoso ... Michael L Dustin
    TCR and CD40L microclusters are linked in synaptic ectosomes (extracellular vesicles) and released in the immunological synapse by helper T cells and induce dendritic cell maturation and cytokine production.
    1. Neuroscience

    Loss of Cdc42 leads to defects in synaptic plasticity and remote memory recall

    Il Hwan Kim, Hong Wang ... Ryohei Yasuda
    Conditional knockout of the small GTPase Cdc42 in excitatory neurons of the mouse forebrain leads to impaired long-term synaptic plasticity and impaired retrieval of remote memory.
    1. Cell Biology
    2. Neuroscience

    Restraint of presynaptic protein levels by Wnd/DLK signaling mediates synaptic defects associated with the kinesin-3 motor Unc-104

    Jiaxing Li, Yao V Zhang ... Catherine A Collins
    Synaptic defects previously attributed to loss of kinesin function are found to be mediated by the Wnd/DLK axonal injury signaling pathway, which restrains the total levels of presynaptic proteins in response to their accumulation.
    1. Cell Biology
    2. Neuroscience

    Intact synapse structure and function after combined knockout of PTPδ, PTPσ, and LAR

    Javier Emperador-Melero, Giovanni de Nola, Pascal S Kaeser
    Leukocyte common antigen-related receptor protein tyrosine phosphatases (LAR-RPTPs) are precisely localized to synaptic appositions, but do not control the assembly and function of the presynaptic nerve terminal.
    1. Neuroscience

    KIF2C regulates synaptic plasticity and cognition in mice through dynamic microtubule depolymerization

    Rui Zheng, Yonglan Du ... Junyu Xu
    KIF2C plays an important role in synaptic plasticity and cognition behaviors in mice by regulating activity-dependent microtubule dynamic.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Auxiliary subunits keep AMPA receptors compact during activation and desensitization

    Jelena Baranovic, Andrew JR Plested
    The auxiliary protein Stargazin limits the conformational dynamics of AMPA-type glutamate receptors in cell membranes, as revealed by 'molecular rulers' deployed on the seconds to milliseconds timescale.
    1. Neuroscience

    Analysis of rod/cone gap junctions from the reconstruction of mouse photoreceptor terminals

    Munenori Ishibashi, Joyce Keung ... Stephen C Massey
    Each cone terminal is electrically coupled to around 50 nearby rods, forming a switchable circuit, known as the secondary rod pathway, in which all gap junction channels participate.
    1. Medicine
    2. Neuroscience

    Two de novo GluN2B mutations affect multiple NMDAR-functions and instigate severe pediatric encephalopathy

    Shai Kellner, Abeer Abbasi ... Shai Berlin
    Two novel mutations in the GRIN2B gene reduce glutamate affinity by >1000-fold, reduce the receptors proton-sensitivity, and exert a dominant-negative effect over receptors in neurons.

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