A combination of cellular, biochemical, genetic and genomic techniques have revealed a new molecular player in the production of fat cells in mice, which could improve our understanding of obesity.
Although the preinitiation complex for transcriptional initiation by RNA polymerase II contains highly conserved general transcription factors, there are kinetic and compositional differences in the initiation process among eukaryotic species.
Gene analyses reveal the abnormal DNA methylation and expression of the genes essential for spermatogenesis as a cause of spermatogenic defects in offspring induced by maternal exposure of a chemical.
Francisco J Herrera, Teppei Yamaguchi ... Robert Tjian
An orphan TBP-associated factor, TAF9B, works in conjunction with the histone acetyl-transferase PCAF as transcriptional co-regulators of neuronal differentiation.
Physical and functional interactions between HNF4A and TAF4 coordinate HNF4A genomic occupancy with pre-initiation complex formation to activate post-natal hepatocyte gene expression.
Glenn A Maston, Lihua Julie Zhu ... Michael R Green
The transcription machinery used to regulate gene expression and self-renewal in human embryonic stem cells is different from that found in other cells.
The switch from mitotic cell cycles to the one meiotic cell cycle in each generation is triggered through dramatic upregulation of a broad gene expression program by transcriptional regulator STRA8.