153 results found
    1. Developmental Biology

    Developmentally regulated Tcf7l2 splice variants mediate transcriptional repressor functions during eye formation

    Rodrigo M Young, Kenneth B Ewan ... Stephen W Wilson
    The inclusion of a new alternatively spliced exon in Tcf7l2 can switch its function to repress transcription of Wnt target genes.
    1. Developmental Biology

    Compensatory growth renders Tcf7l1a dispensable for eye formation despite its requirement in eye field specification

    Rodrigo M Young, Thomas A Hawkins ... Stephen W Wilson
    Disruptions to eye field size have little impact on final eye size due to tissue compensatory mechanisms.
    1. Cancer Biology
    2. Cell Biology

    TCF7L1 promotes skin tumorigenesis independently of β-catenin through induction of LCN2

    Amy T Ku, Timothy M Shaver ... Hoang Nguyen
    Overexpression of TCF7L1 overrides oncogenic Ras-induced senescence, induces cell migration, and promotes growth of skin squamous cell carcinoma independently of its interaction with β-catenin.
    1. Developmental Biology

    A β-catenin-driven switch in TCF/LEF transcription factor binding to DNA target sites promotes commitment of mammalian nephron progenitor cells

    Qiuyu Guo, Albert Kim ... Andrew P McMahon
    β-Catenin-mediated expansion of nephron progenitors is independent of direct β-catenin/chromatin engagement, while progenitor induction proceeds with a β-catenin-driven switch of repressive TCFL1/TCFL2 to activating TCF7/LEF1 factors on transcriptionally poised enhancers.
    1. Developmental Biology

    TAF7L modulates brown adipose tissue formation

    Haiying Zhou, Bo Wan ... Robert Tjian
    TAF7L acts as a molecular switch that regulates the development of mesenchymal stem cells.
    Short Report Updated
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    1. Cancer Biology
    2. Chromosomes and Gene Expression

    Polysome-CAGE of TCL1-driven chronic lymphocytic leukemia revealed multiple N-terminally altered epigenetic regulators and a translation stress signature

    Ariel Ogran, Tal Havkin-Solomon ... Rivka Dikstein
    Examination of the changes in the transcription start site selection in TCL1-driven chronic lymphocytic leukemia and their impact on mRNA translation revealed a marked elevation of intra-genic cryptic promoters, which are predicted to generate multiple N-terminally truncated or modified proteins.
    1. Cell Biology
    2. Developmental Biology

    Dual functions of TAF7L in adipocyte differentiation

    Haiying Zhou, Tommy Kaplan ... Robert Tjian
    A combination of cellular, biochemical, genetic and genomic techniques have revealed a new molecular player in the production of fat cells in mice, which could improve our understanding of obesity.
    1. Immunology and Inflammation
    2. Stem Cells and Regenerative Medicine

    β-catenin and γ-catenin are dispensable for T lymphocytes and AML leukemic stem cells

    Xin Zhao, Peng Shao ... Hai-Hui Xue
    The generation and characterization of true β-catenin null mutant mice conclusively demonstrate that β-catenin is dispensable for T lymphocytes and leukemia stem cells, providing clarifications on a long-standing controversy.
    Short Report Updated
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    1. Immunology and Inflammation

    LMO2 is essential to maintain the ability of progenitors to differentiate into T-cell lineage in mice

    Ken-ichi Hirano, Hiroyuki Hosokawa ... Katsuto Hozumi
    LMO2 plays an important role in the maintenance of T lymphocyte competence and survival of pre-thymic progenitors by regulating the expression of Bcl11a and Tcf7 genes.
    1. Developmental Biology

    Sox17 and β-catenin co-occupy Wnt-responsive enhancers to govern the endoderm gene regulatory network

    Shreyasi Mukherjee, Praneet Chaturvedi ... Aaron M Zorn
    Genomic analysis of Xenopus gastrula reveal that the transcription factor Sox17 interacts with the Wnt signaling effector ß-catenin on enhancers to regulate the transcriptional program underlying endoderm germ layer formation.

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