293 results found
    1. Computational and Systems Biology
    2. Immunology and Inflammation

    Stimulation strength controls the rate of initiation but not the molecular organisation of TCR-induced signalling

    Claire Y Ma, John C Marioni ... Arianne C Richard
    The strength of TCR signalling determines the rate at which cells initiate a tightly coordinated signalling programme, without altering its organization.
    1. Immunology and Inflammation

    Regulation of positive and negative selection and TCR signaling during thymic T cell development by capicua

    Soeun Kim, Guk-Yeol Park ... Yoontae Lee
    Deficiency of capicua, a transcription factor that suppresses autoimmunity, impairs positive and negative selection processes by attenuating TCR signaling in CD4+CD8+ double-positive thymocytes.
    1. Cell Biology
    2. Immunology and Inflammation

    T-cell receptor (TCR) signaling promotes the assembly of RanBP2/RanGAP1-SUMO1/Ubc9 nuclear pore subcomplex via PKC-θ-mediated phosphorylation of RanGAP1

    Yujiao He, Zhiguo Yang ... Yingqiu Li
    T-cell receptor signaling actively regulates gating of the nuclear pore complex (NPC) in T cells by inducing translocation of protein kinase C-θ to the NPC to promote the sumoylation of RanGAP1.
    1. Immunology and Inflammation

    Pak2 is required for actin cytoskeleton remodeling, TCR signaling, and normal thymocyte development and maturation

    Hyewon Phee, Byron B Au-Yeung ... Arthur Weiss
    The p21-activated kinase 2 (Pak2) is an essential regulator that governs the actin cytoskeleton-dependent signaling to ensure normal thymocyte development, maturation and egress.
    1. Immunology and Inflammation

    Optogenetic control shows that kinetic proofreading regulates the activity of the T cell receptor

    O Sascha Yousefi, Matthias Günther ... Wolfgang WA Schamel
    Controlling the duration of ligand binding to the T cell receptor by light shows that T cells discriminate stimulatory from non-stimulatory ligands by measuring the dynamics of ligand binding.
    1. Evolutionary Biology
    2. Immunology and Inflammation

    Enhancing and inhibitory motifs regulate CD4 activity

    Mark S Lee, Peter J Tuohy ... Michael S Kuhns
    Eutherian CD4 evolved counterbalancing motifs in the extracellular, transmembrane, and intracellular domains that regulate CD4+ T cell responses to peptide antigens presented by class II MHC (pMHCII).
    1. Cell Biology
    2. Immunology and Inflammation

    SNX9-induced membrane tubulation regulates CD28 cluster stability and signalling

    Manuela Ecker, Richard Schregle ... Jeremie Rossy
    Sorting nexin 9, a membrane curvature inducing protein, creates a distinct environment within clusters of the co-receptor CD28 and thereby allows T cell activation to proceed to a successful outcome.
    1. Immunology and Inflammation

    PTPN22 R620W gene editing in T cells enhances low-avidity TCR responses

    Warren Anderson, Fariba Barahmand-pour-Whitman ... David J Rawlings
    Gene editing to generate precisely matched primary human T cell populations demonstrates that the common autoimmune risk allele in the tyrosine phosphatase, PTPN22, promotes signaling in cells expressing a low-avidity, self-reactive TCR specific for a diabetes-associated self-antigen.
    1. Cell Biology
    2. Immunology and Inflammation

    Non-canonical antagonism of PI3K by the kinase Itpkb delays thymocyte β-selection and renders it Notch-dependent

    Luise Westernberg, Claire Conche ... Karsten Sauer
    Antagonistic signaling by the kinases PI3K and Itpkb limits the kinetics and enforces the Notch-dependence of beta-selection – the most important cell-fate determining process in alpha beta T cell development.
    1. Biochemistry and Chemical Biology
    2. Immunology and Inflammation

    Rasgrp1 mutation increases naïve T-cell CD44 expression and drives mTOR-dependent accumulation of Helios+ T cells and autoantibodies

    Stephen R Daley, Kristen M Coakley ... Jeroen P Roose
    A single point mutation in a Ras activator leads to aberrant constitutive mTOR signaling in peripheral T cells that consequently accumulate as abnormal T helper cells and stimulate the production of autoantibodies by B cells.

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