447 results found
    1. Neuroscience

    A robust activity marking system for exploring active neuronal ensembles

    Andreas T Sørensen, Yonatan A Cooper ... Yingxi Lin
    A new system for tagging activated neuronal population offers multiple advantages over existing systems based on immediate early genes, including greater sensitivity and specificity, and suitability for easy application in species other than mice.
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    OGT binds a conserved C-terminal domain of TET1 to regulate TET1 activity and function in development

    Joel Hrit, Leeanne Goodrich ... Barbara Panning
    The epigenetic regulator TET1 is regulated by the nutrient-sensing enzyme OGT in vitro and in cells.
    1. Chromosomes and Gene Expression

    Epigenetic reprogramming by TET enzymes impacts co-transcriptional R-loops

    João C Sabino, Madalena R de Almeida ... Sérgio Fernandes de Almeida
    The deposition of 5-hydroxymethylcytosine epigenetic marks in active genes promotes the annealing of the nascent RNA to the template DNA strand, forming an R-loop.
    1. Cancer Biology

    Lactate-mediated epigenetic reprogramming regulates formation of human pancreatic cancer-associated fibroblasts

    Tushar D Bhagat, Dagny Von Ahrens ... Amit Verma
    Lactate in pancreatic cancer micro-environment can lead to TET enzyme activation and loss of DNA methylation seen in cancer associated fibroblasts.
    1. Chromosomes and Gene Expression

    Adenine methylation is very scarce in the Drosophila genome and not erased by the ten-eleven translocation dioxygenase

    Manon Boulet, Guerric Gilbert ... Lucas Waltzer
    Biochemical, molecular, and genetic analyses show that in Drosophila the epigenetic enzyme TET does not demethylate 6mA, which is scarce in the genome, but rather acts in a catalytic-independent manner.
    1. Chromosomes and Gene Expression

    Sustained TNF-α stimulation leads to transcriptional memory that greatly enhances signal sensitivity and robustness

    Zuodong Zhao, Zhuqiang Zhang ... Bing Zhu
    Sustained TNF-α induction consolidates transcriptional memory for faster, stronger, and more sensitive subsequent induction in an active DNA demethylation-dependent manner for memory genes including CALCB, a therapeutic target for migraine.
    1. Cancer Biology
    2. Cell Biology

    LAST, a c-Myc-inducible long noncoding RNA, cooperates with CNBP to promote CCND1 mRNA stability in human cells

    Limian Cao, Pengfei Zhang ... Mian Wu
    A c-Myc-transcribed long noncoding RNA namely LAST (LncRNA-assisted stabilization of transcripts) collaborates with a cellular factor CNBP to promote the stability of CCND1/cyclin D1 mRNA post-transcriptionally, ensuring the proper G1/Sphase transition of the cell cycle.
    1. Neuroscience

    Bright multicolor labeling of neuronal circuits with fluorescent proteins and chemical tags

    Richi Sakaguchi, Marcus N Leiwe, Takeshi Imai
    A bright and stochastic multicolor labeling method, Tetbow, facilitates millimeters-scale reconstructions of neuronal circuits at a large scale using tissue clearing.
    1. Developmental Biology
    2. Stem Cells and Regenerative Medicine

    Loss of Fam60a, a Sin3a subunit, results in embryonic lethality and is associated with aberrant methylation at a subset of gene promoters

    Ryo Nabeshima, Osamu Nishimura ... Hiroshi Hamada
    Fam60a, a component of the Sin3a complex, is required for embryonic development and regulates methylation at a subset of gene promoters.
    1. Immunology and Inflammation

    Epigenetic remodeling by vitamin C potentiates plasma cell differentiation

    Heng-Yi Chen, Ana Almonte-Loya ... Chan-Wang Jerry Lio
    Vitamin C supports the differentiation of antibody-secreting cells by remodeling the DNA methylome to enhance STAT3 DNA binding.

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