1,377 results found
  1. Research: Theory, models and biology

    Wenying Shou, Carl T Bergstrom ... Frances K Skinner
    Theoretical ideas have a rich history in many areas of biology, and new theories and mathematical models have much to offer in the future.
    Editorial
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    1. Computational and Systems Biology

    Engineering of a synthetic quadrastable gene network to approach Waddington landscape and cell fate determination

    Fuqing Wu, Ri-Qi Su ... Xiao Wang
    A synthetic quadrastable gene network provides a synthetic biology framework to study cell fate determination.
    1. Cell Biology
    2. Computational and Systems Biology

    Bistability of a coupled Aurora B kinase-phosphatase system in cell division

    Anatoly V Zaytsev, Dario Segura-Peña ... Ekaterina L Grishchuk
    Self-activating Aurora B kinase, opposed by an inhibitory phosphatase, forms spatial phosphorylation patterns during cell division.
    1. Evolutionary Biology
    2. Medicine

    Developing a theoretical evolutionary framework to solve the mystery of parturition initiation

    Antonis Rokas, Sam Mesiano ... Louis Muglia
    This review considers the evolutionary processes and physiological mechanisms that maintain or end pregnancy in mammals to formulate general, testable theoretical models that provide insights into the biology of parturition.
    1. Neuroscience
    Illustration of a hand and jigsaw puzzle

    Living Science: Theoretical musings

    Eve Marder
    The best theory papers help experimentalists to identify which of their results might be general and to plan a path through the maze of all possible future experiments.
    1. Ecology

    Positive density dependence acting on mortality can help maintain species-rich communities

    Thomas G Aubier
    Some forms of positive density-dependence can favor species coexistence even if competitive species benefit the most from positive density-dependence.
    1. Physics of Living Systems

    Point of View: Are theoretical results ‘Results’?

    Raymond E Goldstein
    There should be a prominent place for theory within biology papers, both as Results in papers that combine experiment and theory, and as Results in theory papers.
    1. Physics of Living Systems
    2. Structural Biology and Molecular Biophysics

    Allosteric conformational ensembles have unlimited capacity for integrating information

    John W Biddle, Rosa Martinez-Corral ... Jeremy Gunawardena
    The effective higher-order binding cooperativities arising from an ensemble of dynamically interchanging conformations are identified and shown to fully describe integration of binding information at thermodynamic equilibrium.
    1. Cancer Biology
    2. Computational and Systems Biology

    Investigating the replicability of preclinical cancer biology

    Timothy M Errington, Maya Mathur ... Brian A Nosek
    A project to repeat experiments from high-impact papers in cancer biology found that the effects observed in replications were frequently weaker than, or inconsistent with, the effects reported in the original papers.
    1. Ecology

    Oxygen isotopes suggest elevated thermometabolism within multiple Permo-Triassic therapsid clades

    Kévin Rey, Romain Amiot ... Christophe Lécuyer
    Two therapsid clades, dicynodonts and cynodonts, independently acquired and developed an endotherm-like thermoregulation during the Late Permian period, that probably helped them to survive the major global climate and environmental fluctuations of the end-Permian.

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