3,160 results found
    1. Developmental Biology

    Identification of the transcription factor ZEB1 as a central component of the adipogenic gene regulatory network

    Carine Gubelmann, Petra C Schwalie ... Bart Deplancke
    A large-scale transcription factor screen reveals over twenty novel adipogenic regulators: most notably ZEB1, which exerts essential transcriptional control of fat cell differentiation.
    1. Developmental Biology
    2. Neuroscience

    Transcription factors underlying photoreceptor diversity

    Juan M Angueyra, Vincent P Kunze ... Wei Li
    Tools and resources to identify transcriptional regulators that create and maintain differences between photoreceptor subtypes.
    1. Immunology and Inflammation

    SPOP targets the immune transcription factor IRF1 for proteasomal degradation

    Irene Schwartz, Milica Vunjak ... Gijs A Versteeg
    SPOP-dependent degradation of interferon regulatory factor 1 curtails cell-intrinsic innate immunity, thereby contributing to immune resolution.
    1. Neuroscience

    Combinatorial programming of human neuronal progenitors using magnetically-guided stoichiometric mRNA delivery

    Sayyed M Azimi, Steven D Sheridan ... Mehmet Fatih Yanik
    A technology allows rapid screening of vast numbers of transcriptional factor combinatorials on stem cell programming.
    1. Chromosomes and Gene Expression

    A genetic program mediates cold-warming response and promotes stress-induced phenoptosis in C. elegans

    Wei Jiang, Yuehua Wei ... Dengke K Ma
    A gene regulatory program regulating thermal stress response and organismic death.
    1. Computational and Systems Biology
    2. Chromosomes and Gene Expression

    An experimentally validated network of nine haematopoietic transcription factors reveals mechanisms of cell state stability

    Judith Schütte, Huange Wang ... Berthold Göttgens
    A computer model built on insights gained from comprehensive experimental analysis reveals mechanisms of blood stem cell regulation.
    1. Stem Cells and Regenerative Medicine

    Selective amputation of the pharynx identifies a FoxA-dependent regeneration program in planaria

    Carolyn E Adler, Chris W Seidel ... Alejandro Sánchez Alvarado
    A chemical method has been developed for studying single organ regeneration and fate specification of stem cells in an adult organism.
    1. Developmental Biology

    Diversification of heart progenitor cells by EGF signaling and differential modulation of ETS protein activity

    Benjamin Schwarz, Dominik Hollfelder ... Ingolf Reim
    A novel regulatory model for the diversification of cardiac cell subpopulations in Drosophila is established by linking epidermal growth factor signaling with differential activities of key transcription factors.
    1. Microbiology and Infectious Disease

    A virus-packageable CRISPR screen identifies host factors mediating interferon inhibition of HIV

    Molly OhAinle, Louisa Helms ... Michael Emerman
    Host restriction factors that block cross-species transmission also play a role in limiting the replication of highly-adapted HIV-1 in IFN-stimulated cells.
    1. Developmental Biology
    2. Genetics and Genomics

    The transcriptional corepressor CTBP-1 acts with the SOX family transcription factor EGL-13 to maintain AIA interneuron cell identity in Caenorhabditis elegans

    Josh Saul, Takashi Hirose, H Robert Horvitz
    The maintenance of diverse cell identities might be coordinated through the interaction between widely acting transcriptional corepressors and cell-specific transcription factors to repress undesired gene expression in a cell-type-specific manner.

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