5,981 results found
    1. Cell Biology
    2. Computational and Systems Biology

    Limits on information transduction through amplitude and frequency regulation of transcription factor activity

    Anders S Hansen, Erin K O'Shea
    The ability of cells to transmit information encoded in signaling dynamics is fundamentally limited by the gene decoding step.
    1. Chromosomes and Gene Expression

    Condensin controls cellular RNA levels through the accurate segregation of chromosomes instead of directly regulating transcription

    Clémence Hocquet, Xavier Robellet ... Pascal Bernard
    Contrary to the generally accepted model, condensin maintains proper gene expression by promoting the accurate segregation of chromosomes and the partitioning of the RNA-exosome throughout mitosis, instead of directly regulating transcription.
    1. Developmental Biology

    Maternal H3K36 and H3K27 HMTs protect germline development via regulation of the transcription factor LIN-15B

    Chad Steven Cockrum, Susan Strome
    The H3K36 and H3K27 histone methyltransferases MES-4 and PRC2 protect survival of the nascent germline in Caenorhabditis elegans by repressing expression of X-linked genes, including the key transcription factor LIN-15B.
    1. Chromosomes and Gene Expression
    2. Immunology and Inflammation

    Regulation of nuclear transcription by mitochondrial RNA in endothelial cells

    Kiran Sriram, Zhijie Qi ... Zhen Bouman Chen
    Mitochondrial RNAs attach to chromatin and regulate nuclear transcription in endothelial stress response.
    1. Biochemistry and Chemical Biology

    Dynamic regulation of transcription factors by nucleosome remodeling

    Ming Li, Arjan Hada ... Michelle D Wang
    Single molecule DNA unzipping reveals a novel model for the regulation of transcription factors and nucleosome positioning via nucleosome remodeling in yeast.
    1. Chromosomes and Gene Expression

    Regulation of alternative polyadenylation by Nkx2-5 and Xrn2 during mouse heart development

    Keisuke Nimura, Masamichi Yamamoto ... Yasufumi Kaneda
    A tissue-specific transcription factor is involved in the regulation of alternative polyadenylation in conjunction with a transcription termination factor.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Pausing guides RNA folding to populate transiently stable RNA structures for riboswitch-based transcription regulation

    Hannah Steinert, Florian Sochor ... Harald Schwalbe
    The discontinuous speed of transcription enables riboswitch molecules to adopt meta-stable structures in response to the presence of their cognate ligand, thereby gene-regulation by means of structure induced transcription termination can occur.
    1. Biochemistry and Chemical Biology

    Delayed inhibition mechanism for secondary channel factor regulation of ribosomal RNA transcription

    Sarah K Stumper, Harini Ravi ... Jeff Gelles
    Single-molecule observations reveal a mechanism that may be used by multiple competing regulatory proteins to control ribosomal RNA production during rapid bacterial cell growth.
    1. Microbiology and Infectious Disease

    Coordinated regulation of gene expression in Plasmodium female gametocytes by two transcription factors

    Yuho Murata, Tsubasa Nishi ... Masao Yuda
    Sequential expression of two transcription factors that bind to five- and ten-base female-specific cis-acting elements, respectively, promotes differentiation of Plasmodium female gametocytes.
    1. Genetics and Genomics

    Gene regulatory network plasticity predates a switch in function of a conserved transcription regulator

    Isabel Nocedal, Eugenio Mancera, Alexander D Johnson
    Rapid evolutionary rewiring of the meiosis transcription network facilitated a switch in the function of a master regulator from regulating meiosis to regulating biofilm formation.

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