2,258 results found
    1. Neuroscience

    Cell type-specific transcriptomics of hypothalamic energy-sensing neuron responses to weight-loss

    Fredrick E Henry, Ken Sugino ... Scott M Sternson
    Cell type-specific transcriptomics in energy homeostasis neurons has identified hundreds of genes and multiple signaling pathways that are regulated by weight loss in mice, as well as several previously unexamined genes that can regulate appetite and body weight.
    1. Neuroscience

    scRNA-sequencing reveals subtype-specific transcriptomic perturbations in DRG neurons of PirtEGFPf mice in neuropathic pain condition

    Chi Zhang, Ming-Wen Hu ... Yun Guan
    Single-cell RNA-sequencing unraveled cell subtype-specific transcriptomic changes in both injured and uninjured primary sensory neurons after nerve injury and demonstrated transcriptomic sexual dimorphism.
    1. Microbiology and Infectious Disease

    A comparative transcriptomic analysis of replicating and dormant liver stages of the relapsing malaria parasite Plasmodium cynomolgi

    Annemarie Voorberg-van der Wel, Guglielmo Roma ... Thierry Tidiane Diagana
    This comprehensive transcriptomic resource of dormant and replicating malaria liver parasites highlights the dearth of pathways that operate in the hypnozoites and the need to investigate druggability (i.e. selectivity and safety) of core pathways in malaria parasites.
    1. Cell Biology
    2. Microbiology and Infectious Disease

    Profiling the bloodstream form and procyclic form Trypanosoma brucei cell cycle using single-cell transcriptomics

    Emma M Briggs, Catarina A Marques ... Keith R Matthews
    Single-cell transcriptomics of cryopreserved parasites reveals extensive cyclic regulation of mRNA abundance by Trypanosoma brucei during the cell cycle.
    1. Genetics and Genomics

    Comparative transcriptomic analysis reveals translationally relevant processes in mouse models of malaria

    Athina Georgiadou, Claire Dunican ... Aubrey J Cunnington
    Comparative transcriptomics of whole blood can be used to evaluate the systemic host response and its concordance between human and mouse malaria and aid the selection of appropriate models for translational malaria research.
    1. Cell Biology
    2. Computational and Systems Biology

    The transcriptomic response of cells to a drug combination is more than the sum of the responses to the monotherapies

    Jennifer EL Diaz, Mehmet Eren Ahsen ... Gustavo Stolovitzky
    The transcriptomic profiles of the constituent monotherapies of synergistic drug pairs tend to be correlated and result in novel gene expression in the combinations.
    1. Neuroscience

    Single-nucleus transcriptomic analysis of human dorsal root ganglion neurons

    Minh Q Nguyen, Lars J von Buchholtz ... Steve Davidson
    Single-nucleus transcriptomics exposes unique features of human somatosensory neurons and clues that may help resolve repeated problems in translating new experimental approaches for treating pain.
    1. Cell Biology

    Spatial transcriptomics reveals metabolic changes underly age-dependent declines in digit regeneration

    Robert J Tower, Emily Busse ... Mimi C Sammarco
    Metabolic supplementation attenuates age-dependent declines in regeneration.
    1. Cancer Biology
    2. Computational and Systems Biology

    Single-cell transcriptomics identifies Keap1-Nrf2 regulated collective invasion in a Drosophila tumor model

    Deeptiman Chatterjee, Caique Almeida Machado Costa ... Wu-Min Deng
    Comprehensive transcriptomic analyses describe the underlying tumorigenic gene expression state in the invasive Drosophila follicle cells following the loss of epithelial cell polarity and identify a non-canonical role of Keap1-Nrf2 signaling in regulating collective cell invasion.
    1. Neuroscience

    Temporal evolution of single-cell transcriptomes of Drosophila olfactory projection neurons

    Qijing Xie, Maria Brbic ... Hongjie Li
    Single-cell transcriptomes of Drosophila olfactory projection neurons correspond to previously defined cell types, exhibit unique characteristics at different developmental stages, and reveal cell-type-specific gene expression programs in development and function.

Refine your results by:

Type
Research categories