1,419 results found
    1. Biochemistry and Chemical Biology
    2. Plant Biology

    Origin and evolution of transporter substrate specificity within the NPF family

    Morten Egevang Jørgensen, Deyang Xu ... Barbara Ann Halkier
    Phylogenetic and biochemical analyses reveals a shared evolutionary path between biosynthesis and transport of defense metabolites in plants.
    1. Structural Biology and Molecular Biophysics

    High-resolution structures with bound Mn2+ and Cd2+ map the metal import pathway in an Nramp transporter

    Shamayeeta Ray, Samuel P Berry ... Rachelle Gaudet
    Structures of a transition metal transporter spanning the entire Mn2+ transport cycle reveal distinct coordination geometries and dynamic polar networks that enable Mn2+ import, and a Cd2+-bound structure helps explain how Cd2+ behaves differently as a substrate.
    1. Biochemistry and Chemical Biology
    2. Evolutionary Biology

    Mitochondrial copper and phosphate transporter specificity was defined early in the evolution of eukaryotes

    Xinyu Zhu, Aren Boulet ... Paul A Cobine
    Ancient evolutionary signatures reveal mechanistic details of substrate specificity in copper-transporting mitochondria carrier family proteins.
    1. Evolutionary Biology

    Robust and accurate prediction of residue–residue interactions across protein interfaces using evolutionary information

    Sergey Ovchinnikov, Hetunandan Kamisetty, David Baker
    Co-evolving residue pairs in the different components of a protein complex almost always make contact across the protein–protein interface, thus providing powerful restraints for the modeling of protein complexes.
    1. Structural Biology and Molecular Biophysics

    Reconstructing the transport cycle in the sugar porter superfamily using coevolution-powered machine learning

    Darko Mitrovic, Sarah E McComas ... Lucie Delemotte
    Using state-specific contacts inferred from coevolving residue pairs enables us to build models of the various conformational states along the sugar porter functional cycle and reconstruct the free-energy landscape of the process.
    1. Biochemistry and Chemical Biology
    2. Plant Biology

    Correction: Origin and evolution of transporter substrate specificity within the NPF family

    Morten Egevang Jørgensen, Deyang Xu ... Barbara Ann Halkier
    1. Structural Biology and Molecular Biophysics
    2. Chromosomes and Gene Expression

    Selection of chromosomal DNA libraries using a multiplex CRISPR system

    Owen W Ryan, Jeffrey M Skerker ... Jamie HD Cate
    An optimized CRISPR-Cas9 system enables multiplexed genome engineering for evolving biomolecules and pathways from chromosomally integrated DNA libraries.
    1. Structural Biology and Molecular Biophysics

    Crystal structures of bacterial small multidrug resistance transporter EmrE in complex with structurally diverse substrates

    Ali A Kermani, Olive E Burata ... Randy B Stockbridge
    In the bacterial small multidrug transporter EmrE, sidechain rearrangements in the binding site accommodate structurally diverse substrates without major rearrangements of the protein backbone.
    1. Neuroscience

    Tracking multiple conformations occurring on angstrom-and-millisecond scales in single amino-acid-transporter molecules

    Yufeng Zhou, John H Lewis, Zhe Lu
    The present fluorescence polarization microscopy method enables the determination of the spatial orientations and lifetimes of a transporter protein in individual conformational states required for understanding the complex conformational mechanism underlying its function, applicable to investigation of other membrane proteins.
    1. Medicine

    Hepatoenteric recycling is a new disposition mechanism for orally administered phenolic drugs and phytochemicals in rats

    Yifan Tu, Lu Wang ... Ming Hu
    A new disposition mechanism for glucuronides, where liver serves as recycle organ and intestine serves as metabolism organ, is established to better explain the disposition of phenolics in vivo.

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