41 results found
    1. Developmental Biology

    Geometric models for robust encoding of dynamical information into embryonic patterns

    Laurent Jutras-Dubé, Ezzat El-Sherif, Paul François
    Propagation, speed and shapes of genetic waves of expression during development can be modeled by a simple interplay between two transcriptional modules (dynamic/static), which explains robustness and precision of patterning.
    1. Computational and Systems Biology
    2. Developmental Biology

    How enhancers regulate wavelike gene expression patterns

    Christine Mau, Heike Rudolf ... Ezzat El-Sherif
    An experimental and computational system has been developed to investigate how wavelike gene expression patterns are generated during embryonic development.
    1. Developmental Biology

    Dynamic BMP signaling polarized by Toll patterns the dorsoventral axis in a hemimetabolous insect

    Lena Sachs, Yen-Ta Chen ... Siegfried Roth
    During the evolution of insect lineages, a signaling pathway dedicated to pathogen defense was co-opted for a new role in embryonic patterning.
    1. Developmental Biology
    2. Immunology and Inflammation

    The extraembryonic serosa is a frontier epithelium providing the insect egg with a full-range innate immune response

    Chris G C Jacobs, Herman P Spaink, Maurijn van der Zee
    Contrary to the current perception, insect eggs are very capable of defending themselves against pathogens.
    1. Developmental Biology
    2. Chromosomes and Gene Expression

    A universal vector concept for a direct genotyping of transgenic organisms and a systematic creation of homozygous lines

    Frederic Strobl, Anita Anderl, Ernst HK Stelzer
    In transgenesis assays involving diploid model organisms, two clearly distinguishable transformation markers embedded in interweaved, but incompatible Lox site pairs allow the systematic creation of homozygous transgenic lines and minimize the number of wasted animals.
    1. Computational and Systems Biology
    2. Developmental Biology

    A re-inducible gap gene cascade patterns the anterior–posterior axis of insects in a threshold-free fashion

    Alena Boos, Jutta Distler ... Ezzat El-Sherif
    The body axis of insects is divided into different fates using a self-regulatory and threshold-free mechanism.
    1. Cell Biology
    2. Developmental Biology

    The beetle amnion and serosa functionally interact as apposed epithelia

    Maarten Hilbrant, Thorsten Horn ... Kristen A Panfilio
    Late morphogenesis of the insect extraembryonic epithelia involves transient formation of a basal-basal bilayer to coordinate the functional contributions of two discrete tissues.
    1. Evolutionary Biology

    Striking parallels between dorsoventral patterning in Drosophila and Gryllus reveal a complex evolutionary history behind a model gene regulatory network

    Matthias Pechmann, Nathan James Kenny ... Siegfried Roth
    Crucial functions of Toll signalling during dorsoventral axis formation might have evolved convergently in flies and crickets.
    1. Developmental Biology
    2. Genetics and Genomics

    A timer gene network is spatially regulated by the terminal system in the Drosophila embryo

    Erik Clark, Margherita Battistara, Matthew A Benton
    A retracting gradient of the transcription factor Tailless spatiotemporally patterns the Drosophila tail region by modulating the intrinsic dynamics of a regulatory network involving the timer genes caudal, Dichaete, and odd-paired.
    1. Biochemistry and Chemical Biology
    2. Ecology

    ABC transporter functions as a pacemaker for sequestration of plant glucosides in leaf beetles

    Anja S Strauss, Sven Peters ... Antje Burse
    A transport protein enables leaf beetle larvae to take up and store plant toxins and use them as part of their own defense strategy.

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