Carrie E Leonard, Jolie Quiros ... Lisa A Taneyhill
Trigeminal nerve deficits observed in familial dysautonomia, which arises from mutations in ELP1, are due to loss of neural crest-derived TrkA nociceptors, while placode-derived TrkB and TrkC neurons are spared.
Nicholas E Bush, Christopher L Schroeder ... Mitra JZ Hartmann
Primary sensory neurons of the rat whisker system encode contact with objects in terms of the forces exerted on whiskers, rather than the induced whisker movements.
Peripheral injury induces a programmed but reversible transformation of gene expression in somatosensory neurons providing a mechanism to regulate sensory input during wound healing.
Functional imaging of individual sensory afferents that innervate the cranial meninges in a mouse migraine model reveals heightened responsiveness to movement-related meningeal deformations that may underlie headache.
Primary trigeminal neurons encode rotational forces in awake mice as they explore an object with their whiskers, allowing accurate prediction of spiking during behaviour.
Glycolysis is locally enhanced and redirected in zebrafish to generate lactate, which functions as a signaling molecule to fully activate Fgf target genes required for proper sensory and neural development.