170 results found
    1. Cell Biology
    2. Neuroscience

    Gain-of-function variants in the ion channel gene TRPM3 underlie a spectrum of neurodevelopmental disorders

    Lydie Burglen, Evelien Van Hoeymissen ... Joris Vriens
    Newly identified gain-of-function variants indicate TRPM3 as the cause of a spectrum of autosomal dominant neurodevelopmental disorders with frequent cerebellar involvement in humans.
    1. Structural Biology and Molecular Biophysics

    Global alignment and assessment of TRP channel transmembrane domain structures to explore functional mechanisms

    Katherine E Huffer, Antoniya A Aleksandrova ... Kenton J Swartz
    Structure-based alignment of TRP channels enables comparison of structural changes, ion permeation pathways and ligand-binding sites and reveals over-representation of structures that represent non-conducting states.
    1. Structural Biology and Molecular Biophysics

    Structure of a TRPM2 channel in complex with Ca2+ explains unique gating regulation

    Zhe Zhang, Balázs Tóth ... László Csanády
    The 3Å structure and correlated functional analysis of the TRPM2 cation channel from Nematostella vectensis shed light on the molecular mechanisms of TRPM2 regulation by intra- and extracellular Ca2+, and of inactivation of human TRPM2.
    1. Evolutionary Biology

    Sequence and structural conservation reveal fingerprint residues in TRP channels

    Deny Cabezas-Bratesco, Francisco A Mcgee ... Sebastian E Brauchi
    Joint sequence, structure, and phylogenetic analyses identify highly conserved features in transmembrane domains of transient receptor potential (TRP) ion channel proteins that offer a novel explanation for how TRPs could integrate stimuli into cellular signals.
    1. Biochemistry and Chemical Biology

    The molecular appearance of native TRPM7 channel complexes identified by high-resolution proteomics

    Astrid Kollewe, Vladimir Chubanov ... Thomas Gudermann
    High-resolution proteomics in conjunction with biochemical and electrophysiological experiments revealed that the channel-kinase TRPM7 in rodent brain forms macromolecular complexes containing the metal transporters CNNM1-4 and a small G-protein ARL15.
    1. Structural Biology and Molecular Biophysics

    Ligand recognition and gating mechanism through three ligand-binding sites of human TRPM2 channel

    Yihe Huang, Becca Roth ... Juan Du
    High-resolution structures of human TRPM2 in different functional states provided the mechanism underlying ligand recognition, channel activation and inhibition.
    1. Structural Biology and Molecular Biophysics

    Structure-based characterization of novel TRPV5 inhibitors

    Taylor ET Hughes, John Smith Del Rosario ... Vera Y Moiseenkova-Bell
    Structure-based virtual screening reveals multiple novel TRPV5 inhibitors that bind and exert their effect from previously unidentified binding sites as characterized by cryo-electron microscopy and electrophysiology.
    1. Neuroscience
    2. Structural Biology and Molecular Biophysics

    Disease-associated mutations in the human TRPM3 render the channel overactive via two distinct mechanisms

    Siyuan Zhao, Yevgen Yudin, Tibor Rohacs
    Disease-associated mutants of the TRPM3 ion channel are overactive, and they are inhibited by the antiepileptic medication primidone, offering a potential therapeutic intervention to treat this channelopathy.
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    1. Structural Biology and Molecular Biophysics

    Electron cryo-microscopy structure of the canonical TRPC4 ion channel

    Deivanayagabarathy Vinayagam, Thomas Mager ... Stefan Raunser
    Structural insights into the architecture and functional properties of zebrafish TRPC4 are revealed by high-resolution cryo-EM.
    1. Neuroscience

    Anti-nociceptive action of peripheral mu-opioid receptors by G-beta-gamma protein-mediated inhibition of TRPM3 channels

    Sandeep Dembla, Marc Behrendt ... Johannes Oberwinkler
    Pro-nociceptive and pro-inflammatory TRPM3 (transient receptor potential melastatin 3) channels, expressed in somatosensory neurons, are inhibited by activation of Gαi-coupled receptors, such as µ-opioid receptors, in vitro and in vivo.

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