1,277 results found
    1. Biochemistry and Chemical Biology
    2. Cell Biology

    N-glycosylation in the protease domain of trypsin-like serine proteases mediates calnexin-assisted protein folding

    Hao Wang, Shuo Li ... Qingyu Wu
    N-glycans commonly present in the protease domains are required for calnexin-mediated protein folding and intracellular trafficking.
    1. Plant Biology
    2. Evolutionary Biology

    Herbivory-induced volatiles function as defenses increasing fitness of the native plant Nicotiana attenuata in nature

    Meredith C Schuman, Kathleen Barthel, Ian T Baldwin
    A 2-year field study has demonstrated that volatile compounds produced by plants when they are attacked by herbivores act as defenses by attracting predators to the herbivores and increasing the reproduction of the plants.
    1. Immunology and Inflammation

    Characterization and functional analysis of cathelicidin-MH, a novel frog-derived peptide with anti-septicemic properties

    Jinwei Chai, Xin Chen ... Xueqing Xu
    The novel cathelicidin cathelicidin-MH was identified from the skin of M. heymonsivogt frog, which protects against lipopolysaccharide- and cecal ligation and puncture-induced sepsis, effectively ameliorates multi-organ pathology, especially in lung.
    1. Microbiology and Infectious Disease
    2. Structural Biology and Molecular Biophysics

    Colicin E1 opens its hinge to plug TolC

    S Jimmy Budiardjo, Jacqueline J Stevens ... Joanna SG Slusky
    Bacterial warfare protein colicin E1 opens its hinge to plug antibiotic efflux pump TolC and potentiate antibiotics.
    1. Microbiology and Infectious Disease

    Profiling of myristoylation in Toxoplasma gondii reveals an N-myristoylated protein important for host cell penetration

    Malgorzata Broncel, Caia Dominicus ... Moritz Treeck
    Myristoylation of a secreted protein, identified in a global myristoylation analysis of the eukaryotic parasite Toxoplasma gondii, is important for host cell invasion.
    1. Biochemistry and Chemical Biology

    YcgC represents a new protein deacetylase family in prokaryotes

    Shun Tu, Shu-Juan Guo ... Sheng-Ce Tao
    A protein microarray based strategy has identified a bacterial enzyme that represents a new protein deacetylase family.
    1. Cell Biology

    A mitochondria-anchored isoform of the actin-nucleating spire protein regulates mitochondrial division

    Uri Manor, Sadie Bartholomew ... Jennifer Lippincott-Schwartz
    An actin nucleating protein, Spire1C, localizes to the mitochondrial outer membrane and interacts with the endoplasmic reticulum-anchored formin protein INF2 to drive mitochondrial fission.
    1. Biochemistry and Chemical Biology
    2. Microbiology and Infectious Disease

    Fucosylation and protein glycosylation create functional receptors for cholera toxin

    Amberlyn M Wands, Akiko Fujita ... Jennifer J Kohler
    Cholera intoxication of human colonic epithelial cells is dependent on recognition of protein glycosylation and fucosylation, not exclusively on ganglioside recognition as proposed previously.
    1. Plant Biology

    Prioritizing plant defence over growth through WRKY regulation facilitates infestation by non-target herbivores

    Ran Li, Jin Zhang ... Yonggen Lou
    A chewing herbivore induced WRKY transcription factor induces jasmonate-dependent defences and supresses gibbererellin-dependent growth, the latter of which renders rice plants more susceptible to secondary infestation by a piercing-sucking herbivore.
    1. Biochemistry and Chemical Biology
    2. Structural Biology and Molecular Biophysics

    Autoinhibition and regulation by phosphoinositides of ATP8B1, a human lipid flippase associated with intrahepatic cholestatic disorders

    Thibaud Dieudonné, Sara Abad Herrera ... Guillaume Lenoir
    Single particle cryo-electron microscopy associated with functional studies reveal a critical role of N- and C-terminal tails in the autoinhibition of the disease-related ATP8B1-CDC50A lipid flippase, the possible role of phosphorylation in autoinhibition relief, and strong activation by PI(3,4,5)P3.

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