471 results found
    1. Evolutionary Biology

    Tumor evolutionary directed graphs and the history of chronic lymphocytic leukemia

    Jiguang Wang, Hossein Khiabanian ... Raul Rabadan
    A general framework captures the evolutionary routes leading to the formation and progression of tumors.
    1. Cancer Biology

    Use of signals of positive and negative selection to distinguish cancer genes and passenger genes

    László Bányai, Maria Trexler ... László Patthy
    In contrast with earlier conclusions, negative selection has a major role in cancer evolution.
    1. Cancer Biology
    2. Immunology and Inflammation

    Optimal cancer evasion in a dynamic immune microenvironment generates diverse post-escape tumor antigenicity profiles

    Jason T George, Herbert Levine
    Theoretical modeling reveals how stochastic optimal cancer immune evasion via antigen downregulation gives rise to diverse post-escape cancer antigenic profiles in a manner dependent on the immune microenvironment.
    1. Cell Biology
    2. Evolutionary Biology

    TP53 copy number expansion is associated with the evolution of increased body size and an enhanced DNA damage response in elephants

    Michael Sulak, Lindsey Fong ... Vincent J Lynch
    Elephants escaped enhanced cancer susceptibility by evolving more master tumor suppressor genes.
    1. Evolutionary Biology
    2. Genetics and Genomics

    The evolutionary plasticity of chromosome metabolism allows adaptation to constitutive DNA replication stress

    Marco Fumasoni, Andrew W Murray
    Evolutionary adaptation to a constitutive perturbation of DNA replication reveals that adaptive mutations in three conserved pathways interact to restore faithful chromosome replication and segregation.
    1. Cancer Biology
    2. Evolutionary Biology

    Pervasive duplication of tumor suppressors in Afrotherians during the evolution of large bodies and reduced cancer risk

    Juan M Vazquez, Vincent J Lynch
    Duplication of tumor suppressor genes contributed to the evolution of large, long-lived elephants.
    1. Evolutionary Biology
    2. Medicine

    Evolution-based mathematical models significantly prolong response to abiraterone in metastatic castrate-resistant prostate cancer and identify strategies to further improve outcomes

    Jingsong Zhang, Jessica Cunningham ... Robert Gatenby
    Integration of evolutionary dynamics framed through a mathematical model improved outcomes in abiraterone monotherapy for the treatment of metastatic castrate-resistant prostate cancer.
    1. Developmental Biology

    The transcriptional response to tumorigenic polarity loss in Drosophila

    Brandon D Bunker, Tittu T Nellimoottil ... David Bilder
    Loss of polarity in epithelial cells leads to mitogenic cytokine upregulation, via coincident activation by JNK and atypical protein kinase C (aPKC), and Polycomb derepression.
    1. Cancer Biology
    2. Computational and Systems Biology

    Quantifying chromosomal instability from intratumoral karyotype diversity using agent-based modeling and Bayesian inference

    Andrew R Lynch, Nicholas L Arp ... Mark E Burkard
    Chromosomal instability of cancer can be quantitatively measured by phylogenetic analysis of 200 tumor cells while using evolutionary principles to account for cellular selection.
    1. Evolutionary Biology
    2. Genetics and Genomics

    Most cancers carry a substantial deleterious load due to Hill-Robertson interference

    Susanne Tilk, Svyatoslav Tkachenko ... Christopher D McFarland
    The absence of negative selection observed in most cancer genomes can be explained by the intrinsic genome-wide linkage in somatic evolution and creates a substantial proteotoxic load.

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